ArticleJournal of the Royal Society, Interface2021
Association between erythrocyte dynamics and vessel remodelling in developmental vascular networks.
Article in Journal of the Royal Society, Interface, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Complex relationship among vessel diameter, shear stress and blood pressure controlling vessel pruning during angiogenesis.PLoS computational biology · 2026Article
- Predicting red blood cell transport and capillary hemodynamics in angiogenic and tumor vascular networks in silico.Biophysical journal · 2025Article
- Red Blood Cell Distribution and Volume Changes at Capillary Junctions in the Living Human Retina.Investigative ophthalmology & visual science · 2025Article
- Angiogenesis is uncoupled from osteogenesis during calvarial bone regeneration.Nature communications · 2024Article
- Enhanced perfusion following exposure to radiotherapy: A theoretical investigation.PLoS computational biology · 2024Article
- A cell-and-plasma numerical model reveals hemodynamic stress and flow adaptation in zebrafish microvessels after morphological alteration.PLoS computational biology · 2023Article
- Sclerotome-derived PDGF signaling functions as a niche cue responsible for primitive erythropoiesis.Development (Cambridge, England) · 2023Article
- Mathematical models of developmental vascular remodelling: A review.PLoS computational biology · 2023Review
- Red blood cell lingering modulates hematocrit distribution in the microcirculation.Biophysical journal · 2023Article
- Angiogenic Microvascular Wall Shear Stress Patterns Revealed Through Three-dimensional Red Blood Cell Resolved Modeling.Function (Oxford, England) · 2023Article
- Capillary pruning couples tissue perfusion and oxygenation with cardiomyocyte maturation in the postnatal mouse heart.Frontiers in cell and developmental biology · 2023Article
- Red blood cell dynamics in extravascular biological tissues modelled as canonical disordered porous media.Interface focus · 2022Article
- Modeling a 3-D multiscale blood-flow and heat-transfer framework for realistic vascular systems.Scientific reports · 2022Article
- Combining multiaspect factors to predict the risk of childhood hypertension incidence.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Traffic Patterns of the Migrating Endothelium: How Force Transmission Regulates Vascular Malformation and Functional Shunting During Angiogenic Remodelling.Frontiers in cell and developmental biology · 2022Article
- Ly6c as a New Marker of Mouse Blood Vessels: Qualitative and Quantitative Analyses on Intact and Ischemic Retinas.International journal of molecular sciences · 2021Article
- Compressed vessels bias red blood cell partitioning at bifurcations in a hematocrit-dependent manner: Implications in tumor blood flow.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Remodeling of the Microvasculature: May the Blood Flow Be With You.Frontiers in physiology · 2020Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sprouting angiogenesis is an essential vascularization mechanism consisting of sprouting and remodelling. The remodelling phase is driven by rearrangements of endothelial cells (ECs) within the post-sprouting vascular plexus. Prior work has uncovered how ECs polarize and migrate in response to flow-induced wall shear stress (WSS). However, the question of how the presence of erythrocytes (widely known as red blood cells (RBCs)) and their impact on haemodynamics affect vascular remodelling remains unanswered. Here, we devise a computational framework to model cellular blood flow in developmental mouse retina. We demonstrate a previously unreported highly heterogeneous distribution of RBCs in primitive vasculature. Furthermore, we report a strong association between vessel regression and RBC hypoperfusion, and identify plasma skimming as the driving mechanism. Live imaging in a developmental zebrafish model confirms this association. Taken together, our results indicate that RBC dynamics are fundamental to establishing the regional WSS differences driving vascular remodelling via their ability to modulate effective viscosity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.