Evidence map›Paper›PMID 34157853›Full record

ArticleAIDS research and human retroviruses2021

Characterization of HIV Risk Behaviors and Clusters Using HIV-Transmission Cluster Engine Among a Cohort of Persons Living with HIV in Washington, DC.

Brittany Wilbourn, Brittani Saafir-Callaway, Kamwing Jair, Joel O Wertheim, Oliver Laeyendeker, Jeanne A Jordan, Michael Kharfen, Amanda Castel, DC Cohort Executive Committee

Open access · greenAbstract read
In one paragraph

Article in AIDS research and human retroviruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Brittany WilbournDepartment of Epidemiology, Milken Institute School of Public Health, The George Washington University, Washington, District of Columbia, USA.ORCID 0000-0003-3428-1392
Brittani Saafir-CallawayHIV/AIDS, Hepatitis, STD and TB Administration, DC Health, Washington, District of Columbia, USA.
Kamwing JairDepartment of Epidemiology, Milken Institute School of Public Health, The George Washington University, Washington, District of Columbia, USA.
Joel O WertheimDepartment of Medicine, University of California San Diego, LA Jolla, California, USA.
Oliver LaeyendekerDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Jeanne A JordanDepartment of Epidemiology, Milken Institute School of Public Health, The George Washington University, Washington, District of Columbia, USA.
Michael KharfenHIV/AIDS, Hepatitis, STD and TB Administration, DC Health, Washington, District of Columbia, USA.
Amanda CastelDepartment of Epidemiology, Milken Institute School of Public Health, The George Washington University, Washington, District of Columbia, USA.
DC Cohort Executive Committee
Milken Institute · USGovernment of the District of Columbia · USNational Institutes of Health · USUniversity of California San Diego · US

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI David Mitchell Smith · 1994 to 2026
$78.4M
The DC Cohort: A Longitudinal Population-Based Cohort Study of People Living with HIV in Washington, DCR24AI152598 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI Amanda Derryck Castel, Marinella Temprosa · 2020 to 2026
$37.9M
International Studies of the Acquired Immune Deficiency Syndrome (AIDS)ZIAAI000361 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI REDD, ANDREW · 2009 to 2025
$15.8M
Automation and Evaluation of Real-Time Transmission Network-Based HIV Prevention Services in New York CityR01AI135992 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WERTHEIM, JOEL OKRENT · 2018 to 2022
$3.6M
NCATS NIH HHS UL1 TR001442NIAID NIH HHS P30 AI036214NIAID NIH HHS R01 AI135992NIAID NIH HHS R24 AI152598
6 · The paper itself

Abstract

Molecular epidemiology (ME) is one tool used to end the HIV epidemic in the United States. We combined clinical and behavioral data with HIV sequence data to identify any overlap in clusters generated from different sequence datasets; to characterize HIV transmission clusters; and to identify correlates of clustering among people living with HIV (PLWH) in Washington, District of Columbia (DC). First, Sanger sequences from DC Cohort participants, a longitudinal HIV study, were combined with next-generation sequences (NGS) from participants in a ME substudy to identify clusters. Next, demographic and self-reported behavioral data from ME substudy participants were used to identify risks of secondary transmission. Finally, we combined NGS from ME substudy participants with Sanger sequences in the DC Molecular HIV Surveillance database to identify clusters. Cluster analyses used HIV-Transmission Cluster Engine to identify linked pairs of sequences (defined as distance ≤1.5%). Twenty-eight clusters of ≥3 sequences (size range: 3-12) representing 108 (3%) participants were identified. None of the five largest clusters (size range: 5-12) included newly diagnosed PLWH. Thirty-four percent of ME substudy participants (

Indexed as

EpidemicsHIV InfectionsDistrict of ColumbiaHumansMolecular EpidemiologyRisk-TakingUnited StatesDistrict of ColumbiaHIVHIV clustersHIV-TRACEmolecular epidemiology

Identifiers

PMID34157853
PMCPMC8501467
OpenAlexW3173773900

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.