Evidence map›Paper›PMID 34157422›Full record

ArticlePharmacological research2021

Optical control of adenosine A

Marc López-Cano, Ingrid Filgaira, Ernest G Nolen, Gisela Cabré, Jordi Hernando, Dilip K Tosh, Kenneth A Jacobson, Concepció Soler, Francisco Ciruela

Open access · greenAbstract read
In one paragraph

Article in Pharmacological research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Bitopic AJournal of medicinal chemistry · 2025
    Article
  6. Article
  7. Photoswitchable Diazocine Derivative for Adenosine AJournal of the American Chemical Society · 2025
    Article
  8. Pharmacological Management of Psoriasis: Current Landscape and Future Perspectives.Recent advances in inflammation & allergy drug discovery · 2025
    Review
  9. 2-Substituted (N)-Methanocarba AACS pharmacology & translational science · 2024
    Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Optical Control of Adenosine AFrontiers in immunology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Marc López-CanoPharmacology Unit, Department of Pathology and Experimental Therapeutics, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, L'Hospitalet de Llobregat, Spain; Neuropharmacology and Pain Group, Neuroscience Program, Institut d'Investigació Biomèdica de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Spain.
Ingrid FilgairaNeuropharmacology and Pain Group, Neuroscience Program, Institut d'Investigació Biomèdica de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Spain; Immunology Unit, Department of Pathology and Experimental Therapeutics, Faculty of Medicine and Health Sciences, University of Barcelona, L'Hospitalet de Llobregat, Spain.
Ernest G NolenColgate University, Hamilton, NY, USA.
Gisela CabréDepartament de Química, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.
Jordi HernandoDepartament de Química, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.
Dilip K ToshMolecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Kenneth A JacobsonMolecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. Electronic address: kennethj@niddk.nih.gov.
Concepció SolerNeuropharmacology and Pain Group, Neuroscience Program, Institut d'Investigació Biomèdica de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Spain; Immunology Unit, Department of Pathology and Experimental Therapeutics, Faculty of Medicine and Health Sciences, University of Barcelona, L'Hospitalet de Llobregat, Spain. Electronic address: concepciosoler@ub.edu.
Francisco CiruelaPharmacology Unit, Department of Pathology and Experimental Therapeutics, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, L'Hospitalet de Llobregat, Spain; Neuropharmacology and Pain Group, Neuroscience Program, Institut d'Investigació Biomèdica de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Spain. Electronic address: fciruela@ub.edu.
Institut d'Investigació Biomédica de Bellvitge · ESNational Institutes of Health · USUniversitat Autònoma de Barcelona · ESBellvitge University Hospital · ESColgate University · US

Funding

Development Of Drugs Acting At Adenosine ReceptorsZIADK031117 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 2009 to 2025
$10.4M
Intramural NIH HHS ZIA DK031117
6 · The paper itself

Abstract

Psoriasis is a chronic and relapsing inflammatory skin disease lacking a cure that affects approximately 2% of the population. Defective keratinocyte proliferation and differentiation, and aberrant immune responses are major factors in its pathogenesis. Available treatments for moderate to severe psoriasis are directed to immune system causing systemic immunosuppression over time, and thus concomitant serious side effects (i.e. infections and cancer) may appear. In recent years, the G

Indexed as

PhotochemotherapyAdenosineAdenosine A3 Receptor AgonistsAnimalsDisease Models, AnimalInterleukin-23LigandsPsoriasisReceptor, Adenosine A3Signal TransductionSkinAdenosineAdenosine A3 Receptor AgonistsInterleukin-23LigandsMRS5698Receptor, Adenosine A3Adenosine receptorAnti-inflammatoryPhotopharmacologyPsoriasis

Identifiers

PMID34157422
PMCPMC8338915
OpenAlexW3174433772

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.