Evidence map›Paper›PMID 34157349›Full record

Trial reportThe Journal of pediatrics2021

Growth Rates of Infants Randomized to Continuous Positive Airway Pressure or Intubation After Extremely Preterm Birth.

Ariel A Salas, Waldemar A Carlo, Barbara T Do, Edward F Bell, Abhik Das, Krisa P Van Meurs, Brenda B Poindexter, Seetha Shankaran, Noelle Younge, Kristi L Watterberg and 2 more

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in The Journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 1 country.

Ariel A SalasDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, AL. Electronic address: asalas@peds.uab.edu.
Waldemar A CarloDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, AL.
Barbara T DoStatistics and Epidemiology Unit, RTI International, Research Triangle Park, NC.
Edward F BellDepartment of Pediatrics, University of Iowa, Iowa City, IA.
Abhik DasStatistics and Epidemiology Unit, RTI International, Research Triangle Park, NC.
Krisa P Van MeursDepartment of Pediatrics, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, CA.
Brenda B PoindexterDepartment of Pediatrics, Emory University and Children's Healthcare of Atlanta, Atlanta, GA.
Seetha ShankaranDepartment of Pediatrics, Wayne State University, Detroit, MI.
Noelle YoungeDepartment of Pediatrics, Duke University, Durham, NC.
Kristi L WatterbergUniversity of New Mexico Health Sciences Center, Albuquerque, NM.
Rosemary D HigginsNational Institute of Child Health and Human Development, Bethesda, MD; Department of Global and Community Health, George Mason University, Fairfax, VA.
Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
RTI International · USDuke University · USGeorge Mason University · USUniversity of Alabama at Birmingham · USUniversity of Iowa · USEmory University · USLucile Packard Children's Hospital · USUniversity of New Mexico · USWayne State University · US

Funding

Neonatal Research Network Data Coordinating Center (DCC) 2023-2028U24HD095254 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI Abhik Das · 2018 to 2026
$70.2M
Neonatal Research Network Data Coordinating Center (DCC)U10HD036790 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI DAS, ABHIK · 2008 to 2017
$62.3M
Convalescent Plasma to Limit Coronavirus Associated ComplicationsUL1TR003167 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KARP, DANIEL D, MCPHERSON, DAVID D · 2019 to 2023
$45.3M
Data Ctr for the Cooperative Neonatal Research NetworkU01HD036790 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI DAS, ABHIK · 1998 to 2007
$21.8M
NICHD Cooperative Multicenter Neonatal Research NetworkU10HD021373 · NICHD · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI KENNEDY, KATHLEEN A · 1991 to 2015
$6.1M
NICHD Neonatal Research Network -- Cincinnati Clinical CenterUG1HD027853 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI STEPHANIE L MERHAR · 2016 to 2026
$3.7M
Clinical Center for NICHD/Neonatal Research NetworkUG1HD068244 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI Sara Bonamo DeMauro, Eric C Eichenwald · 2016 to 2026
$3.6M
NICHD COPPERATIVE MULTICENTER NEONATAL RESEARCH NETWORKUG1HD040689 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI Myra Helen Wyckoff · 2016 to 2026
$3.5M
NICHD Neonatal Research Network Clinical Center - Case Western Reserve UniversityUG1HD021364 · NICHD · CASE WESTERN RESERVE UNIVERSITY · PI Anna Maria Hibbs · 2016 to 2026
$3.5M
North Carolina Clinical CenterUG1HD040492 · NICHD · DUKE UNIVERSITY · PI CHARLES Michael COTTEN, Matthew Laughon · 2016 to 2026
$3.4M
NICHD Cooperative Multicenter Neonatal Research Network - Utah CenterUG1HD087226 · NICHD · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ROBIN K OHLS · 2016 to 2026
$3.3M
NICHD Neonatal Research Network - Stanford UniversityUG1HD027880 · NICHD · STANFORD UNIVERSITY · PI Valerie Chock · 2016 to 2026
$3.3M
NCATS NIH HHS UL1 TR003167NICHD NIH HHS K23 HD102554NICHD NIH HHS U01 HD036790NICHD NIH HHS U10 HD021373NICHD NIH HHS U10 HD036790NICHD NIH HHS U10 HD068284NICHD NIH HHS U24 HD095254NICHD NIH HHS UG1 HD021364NICHD NIH HHS UG1 HD021385NICHD NIH HHS UG1 HD027851NICHD NIH HHS UG1 HD027853NICHD NIH HHS UG1 HD027856NICHD NIH HHS UG1 HD027880NICHD NIH HHS UG1 HD027904NICHD NIH HHS UG1 HD034216NICHD NIH HHS UG1 HD040492NICHD NIH HHS UG1 HD040689NICHD NIH HHS UG1 HD053089NICHD NIH HHS UG1 HD053109NICHD NIH HHS UG1 HD068244NICHD NIH HHS UG1 HD068263NICHD NIH HHS UG1 HD068270NICHD NIH HHS UG1 HD068278NICHD NIH HHS UG1 HD068284NICHD NIH HHS UG1 HD087226NICHD NIH HHS UG1 HD087229NICHD NIH HHS UG1 HD104252NIDDK NIH HHS K23 DK120960
6 · The paper itself

Abstract

objectiveTo evaluate the effects of early treatment with continuous positive airway pressure (CPAP) on nutritional intake and in-hospital growth rates of extremely preterm (EPT) infants. STUDY

designEPT infants (24

resultsGrowth data were analyzed for 810 of 1316 infants enrolled in SUPPORT (414 in the intervention group, 396 in the control group). The median gestational age was 26 weeks, and the mean birth weight was 839 g. Baseline characteristics, total nutritional intake, and in-hospital comorbidities were not significantly different between the 2 groups. In a regression model, growth rates between birth and 36 weeks of PMA, as well as growth rates during multiple intervals from birth to day 7, days 7-14, days 14-21, days 21-28, day 28 to 32 weeks PMA, and 32-36 weeks PMA did not differ between treatment groups. Independent of treatment group, higher growth rates from day 21 to day 28 were associated with a lower risk of having a Bayley-III cognitive score <85 at 18-22 months corrected age (P = .002).

conclusionsEPT infants randomized to early CPAP did not have higher in-hospital growth rates than infants randomized to early intubation.

Indexed as

Continuous Positive Airway PressureIntubation, IntratrachealChild DevelopmentEnergy IntakeFemaleGestational AgeHumansInfant, Extremely PrematureInfant, NewbornMaleNeurodevelopmental DisordersOximetryPulmonary SurfactantsRespiratory Distress Syndrome, NewbornPulmonary Surfactants

Identifiers

PMID34157349
PMCPMC8478787
OpenAlexW3174995928

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.