ArticleEuropean journal of neurology2021
Predictive factors of smell recovery in a clinical series of 288 coronavirus disease 2019 patients with olfactory dysfunction.
Article in European journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- COVID-19-related chemosensory changes: Findings from a prospective national database.World journal of otorhinolaryngology - head and neck surgery · 2024Article
- One-year psychophysical evaluation of COVID-19-induced olfactory disorders: a prospective cohort study.BMC medicine · 2023Article
- SARS-Cov-2 Cycle Threshold Value and Olfactory Dysfunction in COVID-19 Patients.Iranian journal of otorhinolaryngology · 2023Article
- Therapies for COVID-19-Related Persistent Olfactory Disorders: One of the Good Fruits of the Pandemic.Pathogens (Basel, Switzerland) · 2023Article
- Association between olfactory dysfunction and mood disturbances with objective and subjective cognitive deficits in long-COVID.Frontiers in psychology · 2023Article
- Long-term systemic and mucosal SARS-CoV-2 IgA response and its association with persistent smell and taste disorders.Frontiers in immunology · 2023Article
- The Trajectories of Olfactory Dysfunction from the First to the Omicron Wave: Are We Getting over it?Pathogens (Basel, Switzerland) · 2022Article
- Post-Viral Olfactory Loss: What We Learned from the SARS-CoV-2 Pandemic.Life (Basel, Switzerland) · 2022Article
- Two-Year Follow-Up on Chemosensory Dysfunction and Adaptive Immune Response after Infection with SARS-CoV-2 in a Cohort of 44 Healthcare Workers.Life (Basel, Switzerland) · 2022Article
- Coronavirus disease 2019 (COVID-19)-related smell and taste impairment with widespread diffusion of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) Omicron variant.International forum of allergy & rhinology · 2022Article
- Analysis of Prevalence and Predictive Factors of Long-Lasting Olfactory and Gustatory Dysfunction in COVID-19 Patients.Life (Basel, Switzerland) · 2022Article
- Results from psychophysical tests of smell and taste during the course of SARS-CoV-2 infection: a review.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2022Review
- Post-acute COVID-19 syndrome.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- New Onset of Smell and Taste Loss Are Common Findings Also in Patients With Symptomatic COVID-19 After Complete Vaccination.The Laryngoscope · 2022Article
- The Effects of Persistent Olfactory and Gustatory Dysfunctions on Quality of Life in Long-COVID-19 Patients.Life (Basel, Switzerland) · 2022Article
- Neurologic complications of coronavirus and other respiratory viral infections.Handbook of clinical neurology · 2022Review
- Predictive factors of smell recovery in a clinical series of 288 coronavirus disease 2019 patients with olfactory dysfunction.European journal of neurology · 2021Article
- Chemosensory Dysfunctions Induced by COVID-19 Can Persist up to 7 Months: A Study of Over 700 Healthcare Workers.Chemical senses · 2021Article
- COVID-19 related persistent olfactory disorders represent an unprecedented challenge.American journal of otolaryngologyArticle
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThe aim was to evaluate potential predictive factors of smell recovery in a clinical series of 288 patients presenting olfactory dysfunction (OD) related to coronavirus disease 2019 (COVID-19). Potential correlations were sought between epidemiological, clinical and immunological characteristics of patients and the persistence of OD at 60 days.
methodsCOVID-19 positive patients presenting OD were prospectively recruited from three European hospitals. Baseline clinical and olfactory evaluations were performed within the first 2 weeks after OD onset and repeated at 30 and 60 days. In a subgroup of patients, anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies were measured in serum, saliva and nasal secretions at 60 days.
resultsA total of 288 COVID-19 patients with OD were included in the study. Two weeks after the onset of the loss of smell, 52.4% of patients had OD on psychophysical tests, including 113 cases (39.2%) of anosmia and 38 cases (13.2%) of hyposmia. At 60-day follow-up, 25.4% of the patients presented persistent OD. There was no significant correlation between sex, age, viral load on nasopharyngeal swab or COVID-19 severity and poor olfactory outcome. In a subgroup of 63 patients, it was demonstrated that patients with poor olfactory outcomes at 60 days had lower levels of salivary and nasal immunoglobulin G (IgG) and IgG1, but similar levels of antibodies in the serum.
conclusionsNo clinical markers predicted the evolution of OD at 60 days. Patients with poor olfactory outcome at 60 days had lower saliva and nasal antibodies, suggesting a role for local immune responses in the persistence of COVID-19 related OD.
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