Evidence map›Paper›PMID 34157171›Full record

ArticleJournal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology2021

Decreased Annexin A1 expression enhances sensitivity to docetaxel, cisplatin and 5-fluorouracil combination induction chemotherapy in oral squamous cell carcinoma.

Wenwen Sun, Tongchao Zhao, Timothy O Aladelusi, Wutong Ju, Zhiyuan Zhang, Laiping Zhong, Dongwang Zhu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
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  6. Review
  7. Decreased Annexin A1 expression enhances sensitivity to docetaxel, cisplatin and 5-fluorouracil combination induction chemotherapy in oral squamous cell carcinoma.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Wenwen SunDepartment of Oral & Maxillofacial-Head & Neck Oncology, College of Stomatoloy, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Key Research Institute of Stomatology, Ninth People's Hospital, Shanghai, China.
Tongchao ZhaoDepartment of Oral & Maxillofacial-Head & Neck Oncology, College of Stomatoloy, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Key Research Institute of Stomatology, Ninth People's Hospital, Shanghai, China.
Timothy O AladelusiDepartment of Oral and Maxillofacial Surgery, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Wutong JuDepartment of Oral & Maxillofacial-Head & Neck Oncology, College of Stomatoloy, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Key Research Institute of Stomatology, Ninth People's Hospital, Shanghai, China.
Zhiyuan ZhangDepartment of Oral & Maxillofacial-Head & Neck Oncology, College of Stomatoloy, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Key Research Institute of Stomatology, Ninth People's Hospital, Shanghai, China.
Laiping ZhongDepartment of Oral & Maxillofacial-Head & Neck Oncology, College of Stomatoloy, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Key Research Institute of Stomatology, Ninth People's Hospital, Shanghai, China.
Dongwang ZhuDepartment of Oral & Maxillofacial-Head & Neck Oncology, College of Stomatoloy, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Key Research Institute of Stomatology, Ninth People's Hospital, Shanghai, China.ORCID https://orcid.org/0000-0002-1849-9167
Shanghai Jiao Tong University · CNUniversity of Ibadan · NG

Funding

National Natural Science Foundation of China 81602370National Natural Science Foundation of China 81972525
6 · The paper itself

Abstract

backgroundAnnexin A1, a member of the Annexin superfamily, has been shown to play a vital role in a broad range of molecular and cellular processes. This study aims to explore the relationship between the Annexin A1 expression and the clinical response to cisplatin, docetaxel and 5-fluorouracil (TPF) as induction chemotherapy in patients with oral squamous cell carcinoma (OSCC).

methodsThis study recruited two hundred thirty-two patients from a III/IVA OSCC trial. Immunohistochemistry was used to assess the level of Annexin A1 expression. Overexpression and knockdown methods in HB96, HN4 and CAL27 cell lines were used to assess the role of Annexin A1 in the neoplastic cellular response to chemotherapy.

resultsWe found that reduced expression of Annexin A1 conferred a prognostic benefit from induction chemotherapy based on the TPF drug combination in patients with moderately/poorly differentiated disease. Using an in vitro model, we found that low Annexin A1 enhanced cellular proliferation by activating the EGFR/AKT signalling pathway and inhibiting p27 expression. Furthermore, low Annexin A1 initiated a significant decrease in cell viability after treatment with TPF agents. In addition, downregulation of Annexin A1 promoted apoptosis induced by docetaxel, cisplatin and 5-fluorouracil, and upregulation of Annexin A1 inhibited apoptosis.

conclusionAnnexin A1 may be of prognostic value in patients with locally advanced OSCC who are managed with TPF chemotherapy, as low Annexin A1 promotes chemosensitivity to TPF chemotherapy in oral cancer cells via enhanced caspase-dependent apoptosis.

Indexed as

Annexin A1Carcinoma, Squamous CellHead and Neck NeoplasmsMouth NeoplasmsAntineoplastic Combined Chemotherapy ProtocolsCisplatinDocetaxelFluorouracilHumansInduction ChemotherapySquamous Cell Carcinoma of Head and NeckTaxoidsAnnexin A1CisplatinDocetaxelFluorouracilTaxoidsAnnexin A1biomarkerchemotherapyoral squamous cell carcinoma

Identifiers

PMID34157171
PMCPMC8518620
OpenAlexW3176728247

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.