Evidence map›Paper›PMID 34157024›Full record

ArticlePloS one2021

Reducing stroke burden through a targeted self-management intervention for reducing stroke risk factors in high-risk Ugandans: A protocol for a randomized controlled trial.

Mark Kaddumukasa, Josephine Najjuma, Scovia Nalugo Mbalinda, Martin N Kaddumukasa, Jane Nakibuuka, Christopher Burant, Shirley Moore, Carol Blixen, Elly T Katabira, Martha Sajatovic

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04685408 (A TargEted MAnageMent Intervention for Reducing Stroke Risk Factors in High Risk), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04685408 nacompletednot on this mapstarted 2022, after this paper: background citation

A TargEted MAnageMent Intervention for Reducing Stroke Risk Factors in High Risk

TypeinterventionalSponsorCase Western Reserve UniversityRan2022 to 2024Enrolled276ConditionsStrokeArmsTEAM, ETAU
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Use of the i-PARIHS framework in nutrition and dietetics research and practice: A citation analysis of the literature and case studies.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2025
    Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Mark KaddumukasaDepartment of Medicine, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda.ORCID 0000-0001-7390-7330
Josephine NajjumaDepartment of Nursing, Mbarara University of Science and Technology, Mbarara, Uganda.
Scovia Nalugo MbalindaDepartment of Nursing, College of Health Sciences, Makerere University, Kampala, Uganda.
Martin N KaddumukasaDepartment of Medicine, Mulago Hospital, Kampala, Uganda.
Jane NakibuukaDepartment of Medicine, Mulago Hospital, Kampala, Uganda.
Christopher BurantLouis Stokes VA Medical Center, Geriatric Research Education, and Clinical Center, Cleveland, OH, United States of America.
Shirley MooreFrances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, OH, United States of America.
Carol BlixenNeurological and Behavioral Outcomes Center, University Hospitals Cleveland Medical Center & Case Western Reserve University School of Medicine, Cleveland, OH, United States of America.
Elly T KatabiraDepartment of Medicine, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda.
Martha SajatovicNeurological and Behavioral Outcomes Center, University Hospitals Cleveland Medical Center & Case Western Reserve University School of Medicine, Cleveland, OH, United States of America.
Mulago Hospital · UGUniversity Hospitals of Cleveland · USMbarara University of Science and Technology · UGCase Western Reserve University · USMakerere University · UG

Funding

A Targeted Self-Management Intervention for Reducing Stroke Risk Factors in High Risk UgandansR01NS118544 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI KATABIRA, ELLY T, SAJATOVIC, MARTHA X · 2020 to 2025
$3.0M
NINDS NIH HHS R01 NS118544
6 · The paper itself

Abstract

introductionStroke burden is rapidly increasing globally. Modifiable risk factors offer an opportunity to intervene, and targeting hypertension is a key actionable target for stroke risk reduction in sub-Saharan Africa. This 3-site planned randomized controlled trial builds on promising preliminary data.

methodsA total of 246 Ugandan adults will be recruited randomized to experimental intervention vs. enhanced treatment control. Intervention participants will receive six weekly group-format stroke risk reduction self-management training sessions, and the controls will receive information on cardiovascular risk. The primary study outcome is systolic B.P. measured at baseline, 13-week, 24 weeks (6 months). Secondary outcomes include other biological and behavioral stroke risk factors. DISCUSSION: The curriculum-guided self-management TargetEd MAnageMent Intervention (TEAM) program is anticipated to reduce the stroke burden in Uganda.

trial registrationClinicalTrials.gov identifier: NCT04685408, registered on 28 December 2020.

Indexed as

AdolescentBlack PeopleFemaleHumansHypertensionMaleOutcome Assessment, Health CareQuality of LifeRandomized Controlled Trials as TopicRisk FactorsRisk Reduction BehaviorSelf-ManagementStrokeTime FactorsUganda

Identifiers

PMID34157024
PMCPMC8219138
OpenAlexW3175140653

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.