Evidence map›Paper›PMID 34156939›Full record

ArticleIEEE transactions on pattern analysis and machine intelligence2022

Disease-Image-Specific Learning for Diagnosis-Oriented Neuroimage Synthesis With Incomplete Multi-Modality Data.

Yongsheng Pan, Mingxia Liu, Yong Xia, Dinggang Shen

Open access · greenAbstract read
In one paragraph

Article in IEEE transactions on pattern analysis and machine intelligence, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 117 citations in OpenAlex.

  1. Article
  2. Article
  3. Artificial Intelligence-Empowered Multimodal Learning in Psychiatry: A Scoping Review.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026
    Review
  4. Review
  5. Distribution-Guided Multi-Tracer Brain PET Synthesis from Structural MRI with Class-Conditioned Weighted Diffusion.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. PLASMA-CYCLEGAN: PLASMA BIOMARKER-GUIDED MRI TO PET CROSS-MODALITY TRANSLATION USING CONDITIONAL CYCLEGAN.Proceedings. IEEE International Symposium on Biomedical Imaging · 2025
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Hybrid Multimodality Fusion with Cross-Domain Knowledge Transfer to Forecast Progression Trajectories in Cognitive Decline.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2023
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 3 countries.

Yongsheng Pan
Mingxia Liu
Yong Xia
Dinggang Shen
University of North Carolina at Chapel Hill · USNorthwestern Polytechnical University · CN

Funding

Quantifying Brain Abnormality by Multimodality Neuroimage Analysis,R01AG041721 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIU, MINGXIA · 2012 to 2019
$3.0M
NIA NIH HHS R01 AG041721
6 · The paper itself

Abstract

Incomplete data problem is commonly existing in classification tasks with multi-source data, particularly the disease diagnosis with multi-modality neuroimages, to track which, some methods have been proposed to utilize all available subjects by imputing missing neuroimages. However, these methods usually treat image synthesis and disease diagnosis as two standalone tasks, thus ignoring the specificity conveyed in different modalities, i.e., different modalities may highlight different disease-relevant regions in the brain. To this end, we propose a disease-image-specific deep learning (DSDL) framework for joint neuroimage synthesis and disease diagnosis using incomplete multi-modality neuroimages. Specifically, with each whole-brain scan as input, we first design a Disease-image-Specific Network (DSNet) with a spatial cosine module to implicitly model the disease-image specificity. We then develop a Feature-consistency Generative Adversarial Network (FGAN) to impute missing neuroimages, where feature maps (generated by DSNet) of a synthetic image and its respective real image are encouraged to be consistent while preserving the disease-image-specific information. Since our FGAN is correlated with DSNet, missing neuroimages can be synthesized in a diagnosis-oriented manner. Experimental results on three datasets suggest that our method can not only generate reasonable neuroimages, but also achieve state-of-the-art performance in both tasks of Alzheimer's disease identification and mild cognitive impairment conversion prediction.

Indexed as

AlgorithmsAlzheimer DiseaseBrainHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingNeuroimaging

Identifiers

PMID34156939
PMCPMC9297233
OpenAlexW3176896397

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.