Evidence map›Paper›PMID 34156835›Full record

ArticleAnalytical chemistry2021

Long-Term Metabolomics Reference Material.

Goncalo J Gouveia, Amanda O Shaver, Brianna M Garcia, Alison M Morse, Erik C Andersen, Arthur S Edison, Lauren M McIntyre

Abstract read
In one paragraph

Article in Analytical chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Review
  3. Natural variation suggests candidate genes underlying Caenorhabditis elegans susceptibility to diverse toxicants.Toxicological sciences : an official journal of the Society of Toxicology · 2026
    Article
  4. Article
  5. Metabolite Fraction Libraries for Quantitative NMR Metabolomics.bioRxiv : the preprint server for biology · 2025
    Article
  6. Natural variation suggests candidate genes underlyingbioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Phosphorylated glycosphingolipids are commonly detected in Caenorhabditis elegans lipidomes.Metabolomics : Official journal of the Metabolomic Society · 2025
    Article
  12. Role of UDP-Glycosyltransferase (Chemical research in toxicology · 2024
    Article
  13. Article
  14. Advances in Microbial NMR Metabolomics.Advances in experimental medicine and biology · 2023
    Article
  15. Enhancing cell resistance for production of mixed microbiological reference materials with Salmonella and coliforms by freeze-drying.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022
    Article
  16. Yeast-based reference materials for quantitative metabolomics.Analytical and bioanalytical chemistry · 2022
    Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Goncalo J GouveiaDepartment of Biochemistry & Molecular Biology, University of Georgia, Green Street, Athens, Georgia 30602, United States.ORCID 0000-0002-3022-7332
Amanda O ShaverDepartment of Genetics, University of Georgia, Green Street, Athens, Georgia 30602, United States.
Brianna M GarciaDepartment of Chemistry, University of Georgia, 140, Cedar Street, Athens, Georgia 30602, United States.
Alison M MorseDepartment of Molecular Genetics and Microbiology, University of Florida Genetics Institute, University of Florida, Mowry Road, Gainesville, Florida 32610, United States.
Erik C AndersenDepartment of Molecular Biosciences, Northwestern University, 2205, Tech Drive, Evanston, Illinois 60208, United States.
Arthur S EdisonDepartment of Biochemistry & Molecular Biology, University of Georgia, Green Street, Athens, Georgia 30602, United States.ORCID 0000-0002-5686-2350
Lauren M McIntyreDepartment of Molecular Genetics and Microbiology, University of Florida Genetics Institute, University of Florida, Mowry Road, Gainesville, Florida 32610, United States.

Funding

National Metabolomics Data Repository - nextgen Metabolomics WorkbenchU2CDK119886 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUBRAMANIAM, SHANKAR · 2018 to 2021
$12.7M
Portal for Open Computational Metabolomics Tools - Yr 4 U2C SupplementU2CES030167 · NIEHS · UNIVERSITY OF GEORGIA · PI SCHROEDER, FRANK CLEMENS · 2018 to 2021
$4.2M
NIDDK NIH HHS U2C DK119886NIEHS NIH HHS U2C ES030167
6 · The paper itself

Abstract

The use of quality control samples in metabolomics ensures data quality, reproducibility, and comparability between studies, analytical platforms, and laboratories. Long-term, stable, and sustainable reference materials (RMs) are a critical component of the quality assurance/quality control (QA/QC) system; however, the limited selection of currently available matrix-matched RMs reduces their applicability for widespread use. To produce an RM in any context, for any matrix that is robust to changes over the course of time, we developed iterative batch averaging method (IBAT). To illustrate this method, we generated 11 independently grown

Indexed as

Caenorhabditis elegansEscherichia coliAnimalsMetabolomicsQuality ControlReproducibility of Results

Identifiers

PMID34156835
PMCPMC8996483

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.