Evidence map›Paper›PMID 34156651›Full record

Trial reportAging clinical and experimental research2022

A double-blind randomized controlled trial combining cognitive training (CoRe) and neurostimulation (tDCS) in the early stages of cognitive impairment.

Claudia Rodella, Sara Bernini, Silvia Panzarasa, Elena Sinforiani, Marta Picascia, Silvana Quaglini, Elena Cavallini, Tomaso Vecchi, Cristina Tassorelli, Sara Bottiroli

3 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Aging clinical and experimental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 24 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 4 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04118686 naunknown statusnot on this map

New Approaches for the Treatment of Early Stages of Cognitive Impairment in Neurodegenerative Diseases

TypeinterventionalSponsorIRCCS National Neurological Institute "C. Mondino" FoundationRan2017 to 2020Enrolled19ConditionsCognitive ImpairmentArmsCoRe software training plus non-invasive brain stimulation techniques (anodical tDCS / rTMS), CoRe software training plus sham non-invasive brain stimulation (sham tDCS/ sham rTMS)
NCT06053775 naactive not recruitingnot on this mapstarted 2023, after this paper: background citation

Intervention With Non-Invasive Brain Stimulation and Cognitive Training for Depressive Symptomatology Associated With Breast Cancer (ONCODEP)

TypeinterventionalSponsorUniversity of Santiago de CompostelaRan2023 to 2025Enrolled82ConditionsDepressive Symptoms, Cognitive ImpairmentArmsTranscranial Direct Current Stimulation, Transcranial Alternating Current Stimulation, tES sham, Online Cognitive Training
NCT06278818 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Neural and Clinical Correlates of Rehabilitation in Neurodegenerative Conditions

TypeinterventionalSponsorUniversity of PaviaRan2023 to 2026Enrolled110ConditionsMild Cognitive ImpairmentArmsCognitive Telerehabilitation, Control Condition
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 46 citations in OpenAlex.

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  2. Intervention modalities for brain fog caused by long-COVID: systematic review of the literature.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
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  9. Multisession tDCS combined with intrastimulation training improves emotion recognition in adolescents with autism spectrum disorder.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Claudia RodellaDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy. claudia.rodella@gmail.com.ORCID http://orcid.org/0000-0002-9294-8856
Sara BerniniIRCCS Mondino Foundation, Via Mondino 2, Pavia, Italy. sara.bernini@mondino.it.ORCID http://orcid.org/0000-0001-8615-0242
Silvia PanzarasaDepartment of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, Italy.
Elena SinforianiIRCCS Mondino Foundation, Via Mondino 2, Pavia, Italy.ORCID http://orcid.org/0000-0001-5512-6936
Marta PicasciaIRCCS Mondino Foundation, Via Mondino 2, Pavia, Italy.ORCID http://orcid.org/0000-0001-6774-0159
Silvana QuagliniDepartment of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, Italy.ORCID http://orcid.org/0000-0002-4288-2561
Elena CavalliniDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.ORCID http://orcid.org/0000-0002-2405-3399
Tomaso VecchiDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.ORCID http://orcid.org/0000-0002-2998-1784
Cristina TassorelliDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.ORCID http://orcid.org/0000-0003-1513-2113
Sara BottiroliIRCCS Mondino Foundation, Via Mondino 2, Pavia, Italy.ORCID http://orcid.org/0000-0002-0151-3962
University of Pavia · ITFoundation Center · USGiustino Fortunato University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe prevalence of neurodegenerative diseases is expected to increase over the next years, therefore, new methods able to prevent and delay cognitive decline are needed.

aimsTo evaluate the effectiveness of a combined treatment protocol associating a computerized cognitive training (CoRe) with anodal transcranial direct current stimulation (tDCS).

methodsIn this randomized controlled trial, 33 patients in the early stage of cognitive impairment were assigned to the experimental group (CoRE + real tDCS) or control group (CoRE + sham tDCS). In each group, the intervention lasted 3 consecutive weeks (4 sessions/week). A neuropsychological assessment was administered at baseline (T0), post-intervention (T1) and 6-months later (T2).

resultsThe CoRE + real tDCS group only improved in working memory and attention/processing speed at both T1 and T2. It reported a stable MMSE score at T2, while the CoRE + sham tDCS group worsened. Age, mood, and T0 MMSE score resulted to play a role in predicting treatment effects.

conclusionCombined multi-domain interventions may contribute to preventing or delaying disease progression.

trial registrationTrial registration number (ClinicalTrials.gov): NCT04118686.

Indexed as

Cognition DisordersCognitive DysfunctionTranscranial Direct Current StimulationCognitionDouble-Blind MethodHumansNeuropsychological TestsCognitive trainingInter-individual variabilityMulti-domain interventionNeurodegenerative diseasestDCS

Identifiers

PMID34156651
OpenAlexW3175430908

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.