Evidence map›Paper›PMID 34156640›Full record

ArticleHuman cell2021

MiR-99b-5p suppressed proliferation of human osteoblasts by targeting FGFR3 in osteoporosis.

Muliang Ding, Bo Liu, Xia Chen, Zhengxiao Ouyang, Dan Peng, Yu Zhou

Abstract read
PubMed Publisher
In one paragraph

Article in Human cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. The MicroRNAs in the Pathophysiology of Osteoporosis.International journal of molecular sciences · 2024
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Muliang DingDepartment of Orthopaedics, The Second Xiangya Hospital, Central South University, Changsha, 410001, Hunan, China.
Bo LiuDepartment of Orthopaedics, The Second Xiangya Hospital, Central South University, Changsha, 410001, Hunan, China.
Xia ChenDepartment of Orthopaedics, The Second Xiangya Hospital, Central South University, Changsha, 410001, Hunan, China.
Zhengxiao OuyangDepartment of Orthopaedics, The Second Xiangya Hospital, Central South University, Changsha, 410001, Hunan, China.
Dan PengDepartment of Orthopaedics, The Second Xiangya Hospital, Central South University, Changsha, 410001, Hunan, China.
Yu ZhouDepartment of Emergency Medicine, The Second Xiangya Hospital, Central South University, Changsha, 410001, Hunan, China. zhouyuc7@sina.com.ORCID http://orcid.org/0000-0003-2339-7568
Central South University · CN

Funding

Technological Innovation Guidance Plan of Science and Technology Department of Hunan Province 2018SK52507
6 · The paper itself

Abstract

Osteoporosis is a common skeletal disease characterized by reduced bone mass partially caused by an imbalance between bone resorption and formation. Considering the potential role of microRNAs (miRNAs) in osteoporosis, we attempted to identify deregulated miRNA that participates in the pathogenesis of osteoporosis. We analyzed online datasets for differentially expressed miRNAs and predicted deregulated miRNA target genes, applied these genes for signaling pathway enrichment annotation, and selected the possible miR-99b-5p/FGFR3 axis. Within osteoporosis bone tissues, miR-99b-5p was upregulated and FGFR3 was downregulated. miR-99b-5p overexpression inhibited osteoblast proliferation and osteogenesis-related genes expression, whereas FGFR3 overexpression exerted opposite effects upon the proliferation of osteoblasts and osteogenesis-related genes expression. By direct targeting, miR-99b-5p inhibited FGFR3 expression. Moreover, FGFR3 silencing significantly reversed the roles of miR-99b-5p inhibition in the proliferation of osteoblasts and osteogenesis-related genes expression. In conclusion, we identify a deregulated miRNA/mRNA axis in osteoporosis and osteogenic differentiation, namely the miR-99b-5p/FGFR3 axis; through targeting FGFR3, miR-99b-5p inhibits osteoblast proliferation and activity, which might subsequently affect the bone formation in osteoporosis progression.

Indexed as

AgedCell ProliferationCells, CulturedFemaleGene ExpressionGene Expression Regulation, DevelopmentalHumansMaleMicroRNAsMiddle AgedOsteoblastsOsteogenesisOsteoporosisReceptor, Fibroblast Growth Factor, Type 3Signal TransductionFGFR3 protein, humanMicroRNAsMIRN99 microRNA, humanReceptor, Fibroblast Growth Factor, Type 3FGFR3miR-99b-5pOsteoblastOsteoporosisThe Ras signaling

Identifiers

PMID34156640
OpenAlexW3175602048

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.