Evidence map›Paper›PMID 34156552›Full record

ArticleEuropean radiology2022

[

Stephan Skawran, Antonio G Gennari, Manuel Dittli, Valerie Treyer, Urs J Muehlematter, Alexander Maurer, Irene A Burger, Cäcilia Mader, Olivia Messerli, Hannes Grünig and 5 more

Open access · hybridAbstract read
In one paragraph

Article in European radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.

  1. COVID-19 vaccine associated axillary lymphadenopathy - A systematic review.Cancer treatment and research communications · 2022
    Pooled it
  2. Review
  3. Review
  4. Role of COVID-19 Vaccine in the Management of Gynecologic Oncology Lymphadenopathies.International journal of environmental research and public health · 2024
    Observational
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Prolonged generalized immune response onRadiology case reports · 2023
    Article
  11. [Diagnostics (Basel, Switzerland) · 2023
    Article
  12. Axillary Lymph Node Uptake onMolecular imaging and radionuclide therapy · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. [Clinical and translational imaging · 2023
    Article
  18. Article
  19. Article
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Stephan SkawranDepartment of Nuclear Medicine, University Hospital Zurich, Rämistrasse 100, CH-8091, Zurich, Switzerland.
Antonio G GennariDepartment of Nuclear Medicine, University Hospital Zurich, Rämistrasse 100, CH-8091, Zurich, Switzerland.
Manuel DittliDepartment of Nuclear Medicine, University Hospital Zurich, Rämistrasse 100, CH-8091, Zurich, Switzerland.
Valerie TreyerDepartment of Nuclear Medicine, University Hospital Zurich, Rämistrasse 100, CH-8091, Zurich, Switzerland.
Urs J MuehlematterDepartment of Nuclear Medicine, University Hospital Zurich, Rämistrasse 100, CH-8091, Zurich, Switzerland.
Alexander MaurerDepartment of Nuclear Medicine, University Hospital Zurich, Rämistrasse 100, CH-8091, Zurich, Switzerland.
Irene A BurgerDepartment of Nuclear Medicine, University Hospital Zurich, Rämistrasse 100, CH-8091, Zurich, Switzerland.
Cäcilia MaderDepartment of Nuclear Medicine, University Hospital Zurich, Rämistrasse 100, CH-8091, Zurich, Switzerland.
Olivia MesserliUniversity of Zurich, Zurich, Switzerland.
Hannes GrünigDepartment of Nuclear Medicine, University Hospital Zurich, Rämistrasse 100, CH-8091, Zurich, Switzerland.
Catherine GebhardDepartment of Nuclear Medicine, University Hospital Zurich, Rämistrasse 100, CH-8091, Zurich, Switzerland.
Martin W HuellnerDepartment of Nuclear Medicine, University Hospital Zurich, Rämistrasse 100, CH-8091, Zurich, Switzerland.
Alessandra Curioni-FontecedroUniversity of Zurich, Zurich, Switzerland.
Christoph BergerUniversity of Zurich, Zurich, Switzerland.
Michael MesserliDepartment of Nuclear Medicine, University Hospital Zurich, Rämistrasse 100, CH-8091, Zurich, Switzerland. michael.messerli@usz.ch.
University of Zurich · CHUniversity Hospital of Zurich · CHKantonsspital Baden · CH

Funding

GE Healthcare unrelated to current study
6 · The paper itself

Abstract

objectivesTo assess the frequency, intensity, and clinical impact of [

methodsOne hundred forty patients referred for FDG PET/CT during February and March 2021 after first or second vaccination with Pfizer-BioNTech or Moderna were retrospectively included. FDG-avidity of ipsilateral axillary lymph nodes was measured and compared. Assuming no knowledge of prior vaccination, metastatic risk was analyzed by two readers and the clinical impact was evaluated.

resultsFDG PET/CT showed FDG-avid lymph nodes ipsilateral to the vaccine injection in 75/140 (54%) patients with a mean SUV

conclusionsFDG-avid axillary lymph nodes are common after COVID-19 vaccination. The avidity of lymph nodes is more frequent in Moderna compared to that in Pfizer-BioNTech vaccines. To avoid relatively frequent clinical dilemmas, we recommend carefully taking the history for prior vaccination in patients undergoing FDG PET/CT and administering the vaccine contralateral to primary cancer. KEY POINTS: • PET/CT showed FDG-avid axillary lymph nodes ipsilateral to the vaccine injection site in 54% of 140 oncological patients after COVID-19 vaccination. • FDG-avid lymphadenopathy was observed significantly more frequently in Moderna compared to patients receiving Pfizer-BioNTech-vaccines. • Patients should be screened for prior COVID-19 vaccination before undergoing PET/CT to enable individually tailored recommendations for clinical management.

Indexed as

COVID-19COVID-19 Vaccines2019-nCoV Vaccine mRNA-1273BNT162 VaccineFluorodeoxyglucose F18HumansLymph NodesPositron Emission Tomography Computed TomographyRetrospective StudiesSARS-CoV-2Vaccination2019-nCoV Vaccine mRNA-1273BNT162 VaccineCOVID-19 VaccinesFluorodeoxyglucose F18COVID-19 vaccinesFluorodeoxyglucose F18Lymph nodesPositron-emission tomography

Identifiers

PMID34156552
PMCPMC8217971
OpenAlexW3175751839

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.