Evidence map›Paper›PMID 34156525›Full record

Observational studyClinical research in cardiology : official journal of the German Cardiac Society2022

Cardiac autonomic function and cognitive performance in patients with atrial fibrillation.

Peter Hämmerle, Stefanie Aeschbacher, Anne Springer, Ceylan Eken, Michael Coslovsky, Gilles Dutilh, Giorgio Moschovitis, Nicolas Rodondi, Patricia Chocano, David Conen and 3 more

Registry-linked trialAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Clinical research in cardiology : official journal of the German Cardiac Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02105844 (Swiss Atrial Fibrillation Cohort Study - SWISS AF), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02105844 active not recruitingnot on this map

Swiss Atrial Fibrillation Cohort Study - SWISS AF

TypeobservationalSponsorUniversity Hospital, Basel, SwitzerlandRan2014 to 2030Enrolled2,415ConditionsAtrial Fibrillation
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Peter HämmerleDepartment of Cardiology, Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland.
Stefanie AeschbacherDepartment of Cardiology, Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland.
Anne SpringerDepartment of Cardiology, Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland.
Ceylan EkenDepartment of Cardiology, Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland.
Michael CoslovskyDepartment of Cardiology, Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland.
Gilles DutilhDepartment Clinical Research, University of Basel, Basel, Switzerland.
Giorgio MoschovitisDepartment of Cardiology, Hospedale Regionale Di Lugano, Lugano, Switzerland.
Nicolas RodondiInstitute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.
Patricia ChocanoInstitute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.
David ConenPopulation Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada.
Stefan OsswaldDepartment of Cardiology, Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland.
Michael Kühne *Department of Cardiology, Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland.
Christine S Zuern *Department of Cardiology, Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland. christine.meyerzuern@usb.ch.ORCID http://orcid.org/0000-0001-6625-284X

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 33CS30_1148474Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 33CS30_177520
6 · The paper itself

Abstract

backgroundAtrial fibrillation (AF) is associated with loss of cognition and dementia. Cardiac autonomic dysfunction has been linked to cognitive decline. We aimed to investigate if reduced cardiac autonomic function (CAF) is associated with cognitive impairment in AF patients.

methodsPatients with paroxysmal, persistent and permanent AF were enrolled from a multicenter cohort study if they had AF ("AF group") or sinus rhythm ("SR group") on a baseline 5 min ECG recording. Parameters quantifying CAF (heart rate variability triangular index (HRVI), mean heart rate (MHR), RMSSD, SDNN, total power and power in the VLF, LF, HF ranges) were calculated. We used the Montreal Cognitive Assessment (MoCA) to assess global cognitive function.

results1685 AF patients with a mean age of 73 ± 8 years, 29% females, were included. MoCA score was 24.5 ± 3.2 in the AF group (N = 710 patients) and 25.4 ± 3.2 in the SR group (N = 975 patients). After adjusting for multiple confounders, lower HRVI was associated with lower MoCA scores, both in the SR group [β = 0.049; 95% confidence interval (CI) 0.016-0.081; p = 0.003] and in the AF group (β = 0.068; 95% CI 0.020-0.116; p = 0.006). In the AF group, higher MHR was associated with a poorer performance in the MoCA (β =  - 0.008; 95% CI - 0.014 to - 0.002; p = 0.014). We found no convincing evidence of association for other CAF parameters with cognition.

conclusionOur data suggest that impaired CAF is associated with worse cognitive performance in patients with AF. Among standard HRV parameters, HRVI might be the most promising ECG index.

trial registrationClinicalTrials.gov Identifier: NCT02105844.

Indexed as

AgedAtrial FibrillationAutonomic Nervous SystemCognition DisordersElectrocardiographyFemaleHeart RateHumansMaleProspective StudiesRisk FactorsAtrial fibrillationCardiac autonomic functionHeart rate variabilityMontreal Cognitive AssessmentNeurocognitive function

Identifiers

PMID34156525
PMCPMC8766386

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.