Evidence map›Paper›PMID 34156393›Full record

ReviewBiomedicines2021

Iron Oxide-Based Magneto-Optical Nanocomposites for In Vivo Biomedical Applications.

Nisha Lamichhane, Shalini Sharma, Parul, Anita Kamra Verma, Indrajit Roy, Tapas Sen

Open access · goldAbstract readReview
In one paragraph

Review in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. 3D Computational Modeling of FeNanotechnology, science and applications · 2025
    Article
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Nisha LamichhaneNano-Biomaterials Research Group, School of Natural Sciences, University of Central Lancashire, Preston PR1 2HE, UK.ORCID 0000-0001-5049-8976
Shalini SharmaDepartment of Chemistry, University of Delhi, Delhi 110007, India.
ParulDepartment of Chemistry, University of Delhi, Delhi 110007, India.
Anita Kamra VermaNano Biotech Lab, Department of Zoology, Kirori Mal College, University of Delhi, Delhi 110007, India.
Indrajit RoyDepartment of Chemistry, University of Delhi, Delhi 110007, India.
Tapas SenNano-Biomaterials Research Group, School of Natural Sciences, University of Central Lancashire, Preston PR1 2HE, UK.
University of Delhi · INUniversity of Lancashire · GB

Funding

UK-India Education and Research Initiative IND/Cont/G 16-17/62
6 · The paper itself

Abstract

Iron oxide nanoparticles (IONPs) have played a pivotal role in the development of nanomedicine owing to their versatile functions at the nanoscale, which facilitates targeted delivery, high contrast imaging, and on-demand therapy. Some biomedical inadequacies of IONPs on their own, such as the poor resolution of IONP-based Magnetic Resonance Imaging (MRI), can be overcome by co-incorporating optical probes onto them, which can be either molecule- or nanoparticulate-based. Optical probe incorporated IONPs, together with two prominent non-ionizing radiation sources (i.e., magnetic field and light), enable a myriad of biomedical applications from early detection to targeted treatment of various diseases. In this context, many research articles are in the public domain on magneto-optical nanoparticles; discussed in detail are fabrication strategies for their application in the biomedical field; however, lacking is a comprehensive review on real-life applications in vivo, their toxicity, and the prospect of bench-to-bedside clinical studies. Therefore, in this review, we focused on selecting such important nanocomposites where IONPs become the magnetic component, conjugated with various types of optical probes; we clearly classified them into class 1 to class 6 categories and present only in vivo studies. In addition, we briefly discuss the potential toxicity of such nanocomposites and their respective challenges for clinical translations.

Indexed as

cancercarbon quantum dotsdiagnosticsiron oxide nanoparticles (IONPs)magneto-opticaloptical probesplasmonicsemiconductortheranosticstherapeuticsup-conversion

Identifiers

PMID34156393
PMCPMC8000024
OpenAlexW3136463531

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.