Evidence map›Paper›PMID 34156143›Full record

ReviewDiabetes/metabolism research and reviews2022

Innate immunity in latent autoimmune diabetes in adults.

Juan Huang, James Alexander Pearson, F Susan Wong, Li Wen, Zhiguang Zhou

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Diabetes/metabolism research and reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Severe tolvaptan-associated hyperglycemia: a case report.Journal of medical case reports · 2025
    Article
  5. Review
  6. Review
  7. Article
  8. Host gene effects on gut microbiota in type 1 diabetes.Biochemical Society transactions · 2022
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 4 countries.

Juan HuangNational Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
James Alexander PearsonDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.ORCID 0000-0002-2867-2269
F Susan WongDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.
Li WenDepartment of Internal Medicine, Section of Endocrinology, School of Medicine, Yale University, New Haven, Connecticut, USA.
Zhiguang ZhouNational Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.ORCID 0000-0002-0374-1838
Central South University · CNInstitute of Infection and Immunity · CAYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Diabetes Research CenterP30DK045735 · NIDDK · YALE UNIVERSITY · PI Kevan C Herold, GERALD I SHULMAN · 1993 to 2026
$44.0M
Antibody and gut bacteria in obesity and T2DR01DK126809 · NIDDK · YALE UNIVERSITY · PI WEN, LI · 2021 to 2024
$1.8M
Investigating the early development of the immune system and islet autoimmunity later in lifeR01HD097808 · NICHD · YALE UNIVERSITY · PI WEN, LI · 2019 to 2021
$1.3M
NCATS NIH HHS UL1 TR001863NICHD NIH HHS R01 HD097808NIDDK NIH HHS P30 DK045735NIDDK NIH HHS R01 DK126809
6 · The paper itself

Abstract

Latent autoimmune diabetes in adults (LADA) is an autoimmune disease that shares some genetic, immunological and clinical features with both type 1 diabetes and type 2 diabetes. Immune cells including CD4

Indexed as

Diabetes Mellitus, Type 1Diabetes Mellitus, Type 2Latent Autoimmune Diabetes in AdultsAnimalsAutoantibodiesCD8-Positive T-LymphocytesHumansImmunity, InnateRatsAutoantibodiesautoimmunediabetes mellitusinnate immune cellsinnate immunitylatent autoimmune diabetes in adults

Identifiers

PMID34156143
PMCPMC8813511
OpenAlexW3171979335

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.