ArticleBiology open2021
Altered germline cyst formation and oogenesis in Tex14 mutant mice.
Article in Biology open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Dynamic blebbing and absence of organelle transfer during mouse oocyte formation.The EMBO journal · 2026Article
- Cyst-independent oocyte phagocytosis builds the female reproductive reserve in mice.EMBO reports · 2026Article
- Microfilament-Myosin II Regulates the Differentiation of Multinucleated Cysts into Oocytes and Influences Oocyte Developmental Potential in Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Evaluating Selective Quality Control in Mammalian Oogenesis: Evidence and Opportunities.Annual review of genetics · 2025Review
- Intercellular bridges are essential for transposon repression and meiosis in the male germline.Nature communications · 2025Article
- HFM1 is essential for the germ cell intercellular bridge transport in primordial follicle formation in mice.Cellular and molecular life sciences : CMLS · 2024Article
- A tug-of-war between germ cell motility and intercellular bridges controls germline cyst formation in mice.Current biology : CB · 2024Article
- The mouse Balbiani body regulates primary oocyte quiescence via RNA storage.Communications biology · 2024Article
- Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2.Nature communications · 2024Article
- Female Germline Cysts in Animals: Evolution and Function.Results and problems in cell differentiation · 2024Review
- Cell-cell interactions during the formation of primordial follicles in humans.Life science alliance · 2023Article
- Making a good egg: human oocyte health, aging, and in vitro development.Physiological reviews · 2023Review
- Branched germline cysts and female-specific cyst fragmentation facilitate oocyte determination in mice.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Insights into in vivo follicle formation: a review of in vitro systems.Histochemistry and cell biology · 2022Review
- Uncoupling cell division and cytokinesis during germline development in metazoans.Frontiers in cell and developmental biology · 2022Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
During oocyte differentiation in mouse fetal ovaries, sister germ cells are connected by intercellular bridges, forming germline cysts. Within the cyst, primary oocytes form via gaining cytoplasm and organelles from sister germ cells through germ cell connectivity. To uncover the role of intercellular bridges in oocyte differentiation, we analyzed mutant female mice lacking testis-expressed 14 (TEX14), a protein involved in intercellular bridge formation and stabilization. In Tex14 homozygous mutant fetal ovaries, germ cells divide to form a reduced number of cysts in which germ cells remained connected via syncytia or fragmented cell membranes, rather than normal intercellular bridges. Compared with wild-type cysts, homozygous mutant cysts fragmented at a higher frequency and produced a greatly reduced number of primary oocytes with precocious cytoplasmic enrichment and enlarged volume. By contrast, Tex14 heterozygous mutant germline cysts were less fragmented and generate primary oocytes at a reduced size. Moreover, enlarged primary oocytes in homozygous mutants were used more efficiently to sustain folliculogenesis than undersized heterozygous mutant primary oocytes. Our observations directly link the nature of fetal germline cysts to oocyte differentiation and development.
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Registered trials
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