Evidence map›Paper›PMID 34155954›Full record

ArticleJournal of biomolecular structure & dynamics2022

Structural insights of the conserved "priming loop" of hepatitis B virus pre-genomic RNA.

Regan M LeBlanc, Wojciech K Kasprzak, Andrew P Longhini, Lukasz T Olenginski, Fardokht Abulwerdi, Stefano Ginocchio, Brigit Shields, Julie Nyman, Maryia Svirydava, Claudia Del Vecchio and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of biomolecular structure & dynamics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Application of NMR to Large RNAs.Journal of molecular biology · 2025
    Review
  5. Hepatitis B Virus Nucleocapsid Assembly.Journal of molecular biology · 2025
    Review
  6. Article
  7. Selective [9-Chembiochem : a European journal of chemical biology · 2025
    Article
  8. Article
  9. Article
  10. Enhanced TROSY Effect in [2-Angewandte Chemie (International ed. in English) · 2024
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Regan M LeBlancBasic Research Laboratory, National Cancer Institute, Frederick, MD, USA.ORCID 0000-0001-9685-3689
Wojciech K KasprzakBasic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Andrew P LonghiniDepartment of Chemistry and Biochemistry, University of Maryland, College Park, MD, USA.
Lukasz T OlenginskiDepartment of Chemistry and Biochemistry, University of Maryland, College Park, MD, USA.
Fardokht AbulwerdiBasic Research Laboratory, National Cancer Institute, Frederick, MD, USA.
Stefano GinocchioBasic Research Laboratory, National Cancer Institute, Frederick, MD, USA.
Brigit ShieldsRNA Biology Laboratory, National Cancer Institute, Frederick, MD, USA.
Julie NymanBasic Research Laboratory, National Cancer Institute, Frederick, MD, USA.
Maryia SvirydavaDepartment of Chemistry and Biochemistry, University of Maryland, College Park, MD, USA.
Claudia Del VecchioDepartment of Molecular Medicine, University of Padua, Padua, Italy.
Joseph IvanicAdvanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
John S SchneeklothChemical Biology Laboratory, National Cancer Institute, Frederick, MD, USA.
Bruce A ShapiroRNA Biology Laboratory, National Cancer Institute, Frederick, MD, USA.
Theodore Kwaku DayieDepartment of Chemistry and Biochemistry, University of Maryland, College Park, MD, USA.ORCID 0000-0002-7119-4362
Stuart F J Le GriceBasic Research Laboratory, National Cancer Institute, Frederick, MD, USA.
National Cancer Institute · USUniversity of Maryland, College Park · USFrederick National Laboratory for Cancer Research · USUniversity of California, Santa Barbara · USUniversity of Padua · IT

Funding

Identification of Nucleic Acid Binding Small MoleculesZIABC011585 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI SCHNEEKLOTH, JOHN · 2014 to 2025
$18.6M
Time resolved SAXS studies on the RP2/Arl3 complex pp.484-485P41GM103622 · NIGMS · ILLINOIS INSTITUTE OF TECHNOLOGY · PI IRVING, THOMAS C · 2012 to 2020
$11.9M
Computational Approaches for RNA StructureFunction DeterminationZIABC008382 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI SHAPIRO, BRUCE · 2009 to 2021
$5.8M
Inhibitor of FtsZ Polymerization in M. tuberculosisR01AI050470 · NIAID · SOUTHERN RESEARCH INSTITUTE · PI REYNOLDS, ROBERT C · 2002 to 2004
$1.7M
Structural studies with regulatory RNAsZIABC011824 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI LE GRICE, STUART F. J. · 2018 to 2021
$1.6M
CCR NIH HHS HHSN261200800001CIntramural NIH HHS ZIA BC008382Intramural NIH HHS ZIA BC011585Intramural NIH HHS ZIA BC011824NCI NIH HHS HHSN261200800001ENIAID NIH HHS R01 AI050470NIGMS NIH HHS P41 GM103622
6 · The paper itself

Abstract

Initiation of protein-primed (-) strand DNA synthesis in hepatitis B virus (HBV) requires interaction of the viral polymerase with a

Indexed as

Hepatitis B virusRNA, ViralGenomicsVirus ReplicationRNA, ViralHepatitis B virusNMR spectroscopyRNA dynamicsRNA structureSERMsmall molecule screen

Identifiers

PMID34155954
PMCPMC10167916
OpenAlexW3177050858

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.