Evidence map›Paper›PMID 34155864›Full record

ArticleInternational journal of fertility & sterility2021

Influence of Autologous

Suada Tinjić, Džihan Abazović, Dušica Ljubić, Danilo Vojvodić, Tatjana Božanović, Mirza Ibrišimović, Sergije Marković, Aleksandar Ljubić

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of fertility & sterility, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04009473 (Platelet Rich Plasma Ovarian in Vitro Activation and Stem Cells Transplantation In Women With Ovarian Failure), which is not on this map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04009473 phase1 / phase2unknown statusnot on this map

Platelet Rich Plasma Ovarian in Vitro Activation and Stem Cells Transplantation In Women With Ovarian Failure

TypeinterventionalSponsorForever Young d.o.o.Ran2019 to 2021Enrolled100ConditionsMenopause, Menopause Ovarian Failure, Ovarian Failure, Premature Ovarian FailureArmsSEGOVA procedure
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
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  5. [Stem cell therapy for premature ovarian insufficiency: a review of clinical evidence and therapeutic strategies].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 8 institutions in 5 countries.

Suada TinjićDepartment of Gynecology, Polyclinic, Korak do Života, Tuzla, Bosnia and Herzegovina.Email: suada.tinjic@gmail.com.
Džihan AbazovićDepartment of Regenerative Medicine, Remedika Hospital, Belgrade, Serbia.
Dušica LjubićDepartment of Gynecology, MediGroup Hospital, Belgrade, Serbia.
Danilo VojvodićFaculty of Medicine, Military Medical School, Belgrade, Serbia.
Tatjana BožanovićDepartment of Gynecology and Obstetrics, Medical School, University of Belgrade, Belgrade, Serbia.
Mirza IbrišimovićDepartment of Gynecology, Polyclinic, Korak do Života, Tuzla, Bosnia and Herzegovina.
Sergije MarkovićDepartment of Histology, Medical School, University of Tuzla, Tuzla, Bosnia and Herzegovina.
Aleksandar LjubićDepartment of Gynecology, Dubrovnik International University, Dubrovnik, Croatia.
Center for Health, Exercise and Sport Sciences · RSMilitary Medical Academy · RSRegenerative Medicine Institute · MXUniversity Clinical Center Tuzla · BAUniversity of Belgrade · RSUniversity of Dubrovnik · HRUniversity of Sarajevo · BAUniversity of Tuzla · BA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPremature ovarian failure (POF) can be found in 1% of women at the age of 35-40, mostly due to unknown causes. PI3K-Akt signaling is associated with both ovarian function and growth of primordial follicles. In this study, we examined the effects of autologous MATERIALS AND

methodsThe longitudinal prospective observational study included 50 patients (between 30 and 50 years) with a diagnosis of POF and infertility. This multicenter study was performed at Jevremova Special Hospital in Belgrade, Saint James Hospital (Malta), and Remedica Skoplje Hospital, between 2015 and 2018. All patients went through numerous laboratory testings, including hormonal status. The autologous bone marrow mesenchymal stem cells (BMSCs) and growth factors were used in combination for activation of ovarian tissue before its re-transplantation. The software package SPSS 20.0 was used for statistical analysis of the results.

resultsDifferences in follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), and progesterone (PG) hormone concentrations before and after 3, 6, and 12 months post-transplantation were tested in correlation with the volume of transplanted ovarian tissue. A significant correlation (P=0.029) was found between the change in E2 level after 3 months and the volume of re-transplanted tissues. Also after re-transplantation, 64% of the patients had follicles resulting in aspiration of oocytes in 25% of positive women with follicles.

conclusionThe SEGOVA method could potentially solve many human reproductive problems in the future due to the large number of patients diagnosed with POF, as well asthe possibility of delaying menopause, thus improving the quality of life and general health (Registration number: NCT04009473).

Indexed as

Growth FactorsOvarianPremature Ovarian FailureStem Cells

Identifiers

PMID34155864
PMCPMC8233920
OpenAlexW3156915240

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.