Evidence map›Paper›PMID 34155626›Full record

ArticleEpilepsia2021

Spike and wave discharges and fast ripples during posttraumatic epileptogenesis.

Udaya Kumar, Lin Li, Anatol Bragin, Jerome Engel

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Udaya KumarDepartment of Neurology, University of California, Los Angeles, Los Angeles, California, USA.ORCID 0000-0003-0725-0195
Lin LiDepartment of Neurology, University of California, Los Angeles, Los Angeles, California, USA.ORCID 0000-0002-9996-9377
Anatol BraginDepartment of Neurology, University of California, Los Angeles, Los Angeles, California, USA.ORCID 0000-0003-1207-8481
Jerome EngelDepartment of Neurology, University of California, Los Angeles, Los Angeles, California, USA.
University of California, Los Angeles · USUniversity of North Texas · US

Funding

The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) Public Engagement CoreU54NS100064 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ENGEL, JEROME NONE, GALANOPOULOU, ARISTEA S · 2017 to 2021
$21.7M
IN VIVO STUDIES OF THE EPILEPTIC HIPPOCAMPUSR01NS033310 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JEROME NONE ENGEL, Richard Staba · 1994 to 2026
$7.5M
New Electrographic Biomarkers of EpileptogenesisR01NS065877 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BRAGIN, ANATOL · 2010 to 2018
$4.0M
New Biomarkers of EpileptogenesisR56NS065877 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BRAGIN, ANATOL · 2019 to 2019
$540k
NINDS NIH HHS R01 NS033310NINDS NIH HHS R01 NS065877NINDS NIH HHS R56 NS065877NINDS NIH HHS U54 NS100064
6 · The paper itself

Abstract

objectiveThe goal of the present study was to determine whether spike and wave discharges (SWDs) and SWDs with superimposed fast ripples (SWDFRs) could be biomarkers of posttraumatic epileptogenesis.

methodsFluid percussion injury was conducted on 13-14-week old male Sprague Dawley rats. Immediately after traumatic brain injury (TBI), they were implanted with microelectrodes in the neocortex, hippocampus, and striatum bilaterally. Age-matched sham rats with the same electrode implantation montage acted as controls. Wideband brain electrical activity was recorded intermittently from Day 1 of TBI, and continued from 2 to 21 weeks after TBI. SWD and SWDFR analysis was performed during the first 2 weeks to investigate whether the occurrence of this pattern predicted development of epilepsy. The remaining 3-21 weeks were used for identifying which rats became epileptic (E+ group) and which did not (E- group).

resultsThe E+ group (n = 9) showed a significant increase in SWD rate in prefrontal cortex during Weeks 1 and 2 after TBI. The E- group showed a significant increase in SWD rate only in the second week. One hundred percent of rats in the E+ group displayed SWDFRs beginning from the first week after TBI. The SWDFR pattern was observed in all recorded brain areas: prefrontal and perilesional cortices, hippocampus, and striatum. None of rats in the E- group showed coexistence of fast ripples with SWDs. SIGNIFICANCE: Occurrence of SWDFRs after TBI, but not an increase in the rate of SWDs, could be a noninvasive electroencephalographic biomarker of posttraumatic epileptogenesis.

Indexed as

Brain Injuries, TraumaticEpilepsyNeocortexAnimalsDisease Models, AnimalElectroencephalographyMaleRatsRats, Sprague-Dawleybiomarkerepilepsyfast ripplesposttraumatic epilepsyspike and wave dischargestraumatic brain injury

Identifiers

PMID34155626
PMCPMC8349888
OpenAlexW3176239810

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.