ArticleWorld journal of surgery2021
Matrix Metalloproteinases (MMP-2) and Tissue Inhibitors of Metalloproteinases (TIMP-2) in Male Inguinal Hernia Patients at Different Ages.
Article in World journal of surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 6 citations in OpenAlex.
- Metabolism, Morphology and Function of the Anterior Abdominal Wall Musculature in Ventral Hernias and After Repair: A Narrative Review and Research Agenda.Journal of personalized medicine · 2026Review
- A mechanistic exploration of IL-1β / p38 MAPK / MMP-2 pathway in inguinal hernia: evidence from clinical specimens and in vitro model.Surgical endoscopy · 2026Article
- The role of serum levels of matrix metalloproteinases and their inhibitors in the etiology of inguinal hernia.Hernia : the journal of hernias and abdominal wall surgery · 2025Article
- Risk factors of recurrence after incisional hernia preperitoneal repair: a long-term retrospective single-center cohort study.Langenbeck's archives of surgery · 2024Article
- Lichtenstein Repair in Inguinal Hernia- A Retrospective Study on the Impact of In-Hospital Costs of Diabetes Mellitus.Current health sciences journalArticle
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
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Abstract
backgroundCollagen metabolism, controlled by matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs), might be related to inguinal hernia formation. It was reported that the incidence of inguinal hernia and the recurrence rate after inguinal hernia repair were higher in the elderly. The objective of the research was to assess the amounts of MMP-2 and TIMP-2 in patients at different ages in order to examine the relationship between age and inguinal hernia occurrence.
methodsThe research included 40 primary inguinal hernia male patients, and four groups were created: 50-59 years old (A group); 60-69 years old (B group); 70-79 years old (C group); 80-89 years old (D group). We got the samples from anterior rectus sheath fascia. Real-time fluorescence quantitative polymerase chain reaction (RT-PCR) and immunohistochemistry were applied to estimate the levels of MMP-2 and TIMP-2.
resultsThe MMP-2 amounts in C and D group were statistically higher than control group (P < 0.05), and the TIMP-2 levels in C and D group were statistically lower than control group (P < 0.05). We found a positive correlation between age and expression levels of MMP-2 (r = 0.537, P < 0.001; r = 0.569, P < 0.001) and a negative correlation between age and TIMP-2 in inguinal hernia patients (r = - 0.759, P < 0.001; r = - 0.759, P < 0.001).
conclusionsIncreased MMP-2 and reduced TIMP-2 may have some relationships with higher inguinal hernia incidence of the elderly.
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