Evidence map›Paper›PMID 34155365›Full record

ArticleEye (London, England)2022

Study of Optimal Perimetric Testing In Children (OPTIC): developing consensus and setting research priorities for perimetry in the management of children with glaucoma.

Dipesh E Patel, Phillippa M Cumberland, Bronwen C Walters, Joseph Abbott, John Brookes, Beth Edmunds, Peng Tee Khaw, Ian Christopher Lloyd, Maria Papadopoulos, Velota Sung and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Eye (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Outcome measures in childhood glaucoma: a systematic review of randomized controlled trials.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023
    Pooled it
  2. Devising and Evaluating an Adaptive Static-Automated Perimetry Test for Children: A Feasibility Study.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026
    Article
  3. Article
  4. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 3 countries.

Dipesh E PatelLife Course Epidemiology and Biostatistics Section, UCL GOS Institute of Child Health, London, UK.
Phillippa M CumberlandLife Course Epidemiology and Biostatistics Section, UCL GOS Institute of Child Health, London, UK.
Bronwen C WaltersUlverscroft Vision Research Group, London, UK.
Joseph AbbottDepartment of Ophthalmology, Birmingham Children's Hospital, Birmingham, UK.
John BrookesGlaucoma Service, Moorfields Eye Hospital NHS Foundation Trust, London, UK.
Beth EdmundsDepartment of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, OR, USA.
Peng Tee KhawNIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.ORCID http://orcid.org/0000-0002-8087-2268
Ian Christopher LloydGreat Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Maria PapadopoulosGlaucoma Service, Moorfields Eye Hospital NHS Foundation Trust, London, UK.
Velota SungBirmingham and Midland Eye Centre, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK.
Mario Cortina-BorjaClinical Epidemiology, Nutrition and Biostatistics Section, UCL GOS Institute of Child Health, London, UK.
Jugnoo S RahiLife Course Epidemiology and Biostatistics Section, UCL GOS Institute of Child Health, London, UK. j.rahi@ucl.ac.uk.
OPTIC Study Group
Moorfields Eye Hospital NHS Foundation Trust · GBGreat Ormond Street Hospital for Children NHS Foundation Trust · GBCity, University of London · GBBirmingham Children's Hospital · GBOregon Health & Science University · USSandwell & West Birmingham Hospitals NHS Trust · GBUlverscroft (United Kingdom) · GBUniversity College London · GB

Funding

Proteomics CoreP30EY010572 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Kate E Keller · 1995 to 2026
$19.4M
NEI NIH HHS P30 EY010572
6 · The paper itself

Abstract

backgroundPerimetry is important in the management of children with glaucoma, but there is limited evidence-based guidance on its use. We report an expert consensus-based study to update guidance and identify areas requiring further research.

methodsExperts were invited to participate in a modified Delphi consensus process. Panel selection was based on clinical experience of managing children with glaucoma and UK-based training to minimise diversity of view due to healthcare setting. Questionnaires were delivered electronically, and analysed to establish 'agreement'. Divergence of opinions was investigated and resolved where possible through further iterations.

results7/9 experts invited agreed to participate. Consensus (≥5/7 (71%) in agreement) was achieved for 21/26 (80.8%) items in 2 rounds, generating recommendations to start perimetry from approximately 7 years of age (IQR: 6.75-7.25), and use qualitative methods in conjunction with automated reliability indices to assess test quality. There was a lack of agreement about defining progressive visual field (VF) loss and methods for implementing perimetry longitudinally. Panel members highlighted the importance of informing decisions based upon individual circumstances-from gauging maturity/capability when selecting tests and interpreting outcomes, to accounting for specific clinical features (e.g. poor IOP control and/or suspected progressive VF loss) when making decisions about frequency of testing.

conclusionsThere is commonality of expert views in relation to implementing perimetry and interpreting test quality in the management of children with glaucoma. However, there remains a lack of agreement about defining progressive VF loss, and utilising perimetry over an individuals' lifetime, highlighting the need for further research.

Indexed as

GlaucomaVisual Field TestsChildConsensusConsensus Statements as TopicHumansReproducibility of ResultsResearchVision DisordersVisual Fields

Identifiers

PMID34155365
PMCPMC9151738
OpenAlexW3173395173

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.