Evidence map›Paper›PMID 34155356›Full record

SynthesisBone marrow transplantation2021

Cardiorespiratory fitness and physical performance after childhood hematopoietic stem cell transplantation: a systematic review and meta-analysis.

Martin Kaj Fridh, Casper Simonsen, Peter Schmidt-Andersen, Anne Anker Nissen, Jesper Frank Christensen, Anders Larsen, Abigail L Mackey, Hanne Bækgaard Larsen, Klaus Müller

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Bone marrow transplantation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Martin Kaj FridhDepartment of Pediatrics and Adolescent Medicine, Copenhagen University Hospital (Rigshospitalet), 2100, Copenhagen, Capital Region, Denmark. martin.kaj.fridh@regionh.dk.ORCID http://orcid.org/0000-0002-1560-0530
Casper SimonsenCenter for Inflammation and Metabolism/Center for Physical Activity (CIM/CFAS), Copenhagen University Hospital (Rigshospitalet), 2100, Copenhagen, Capitol Region, Denmark.
Peter Schmidt-AndersenDepartment of Pediatrics and Adolescent Medicine, Copenhagen University Hospital (Rigshospitalet), 2100, Copenhagen, Capital Region, Denmark.
Anne Anker NissenDepartment of Pediatrics and Adolescent Medicine, Copenhagen University Hospital (Rigshospitalet), 2100, Copenhagen, Capital Region, Denmark.
Jesper Frank ChristensenCenter for Inflammation and Metabolism/Center for Physical Activity (CIM/CFAS), Copenhagen University Hospital (Rigshospitalet), 2100, Copenhagen, Capitol Region, Denmark.
Anders LarsenCopenhagen University Hospitals Centre for Health Research (UCSF), Copenhagen, Denmark.
Abigail L MackeyInstitute of Sports Medicine Copenhagen, Department of Orthopedic Surgery, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Capital Region, Denmark.
Hanne Bækgaard LarsenDepartment of Pediatrics and Adolescent Medicine, Copenhagen University Hospital (Rigshospitalet), 2100, Copenhagen, Capital Region, Denmark.
Klaus MüllerDepartment of Pediatrics and Adolescent Medicine, Copenhagen University Hospital (Rigshospitalet), 2100, Copenhagen, Capital Region, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effects of childhood hematopoietic stem cell transplantation (HSCT) on key organs can impair cardiorespiratory fitness, muscle strength, and physical performance. We aimed to provide an overview of childhood HSCT survivors' status on these parameters compared with healthy controls and discuss current insights into clinical risk factors. We performed a systematic search in six scientific databases, including studies published before April 2019 and performed a meta-analysis on cardiorespiratory fitness. Muscle strength and physical performance status were presented narratively. We included ten studies embodying 517 childhood HSCT survivors (mean 17.8 years at follow-up). The meta-analysis (n = 4 studies) showed that childhood HSCT survivors have lower cardiorespiratory fitness compared with healthy controls (Standard mean difference (SMD) -1.32 [95% CI -1-58 to -1.07]; I

Indexed as

Cardiorespiratory FitnessHematopoietic Stem Cell TransplantationHumansMuscle StrengthPhysical Functional PerformanceSurvivors

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.