ArticleNature biomedical engineering2021
The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans.
Article in Nature biomedical engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 151 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
151 citing papers in PubMed, 1 synthesis or guideline pooled it, 271 citations in OpenAlex.
- From Case Reports to Molecular Insight: Examining the Outcomes and Underlying Mechanisms of Squamous Cell Carcinoma in Breast Implant Patients-A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Once yearly cell-based therapy for sustained and dose-tunable delivery of monoclonal antibodies.Science advances · 2026Article
- Tissue-Preserving Inframammary Fold Breast Augmentation: A 3-Year Clinical Experience.Aesthetic surgery journal · 2026Observational
- Minimally Invasive, Tissue-Preserving Breast Augmentation: Insights From a Large Case Series, Technique and Surgical Pearls.Aesthetic surgery journal · 2026Article
- Tissue Preservation in Primary Breast Augmentation: From Founding Concepts to Early Evidence.Aesthetic surgery journal · 2026Article
- From Bench to Bedside: Clinical Implications of a 4-Micron Surface-Modulated Immune Response in the Era of Breast Tissue Preservation.Aesthetic surgery journal · 2026Review
- Retrospective Validation of a Tissue-Preserving Breast Augmentation Approach: From Native Tissue Geometry to Surgical Practice.Aesthetic surgery journal · 2026Article
- Coordinated Two-Node Blockade of NF-κB and TGF-β/Smad Signaling Attenuates the Foreign Body Response to Prevent Capsular Contracture.Biomedicines · 2026Article
- A modular hydrogel system with independent control of bioadhesion, fibrosis, and stiffness.Science advances · 2026Article
- A Facile and Versatile Technique for Creating Antifibrotic Coatings on Biomedical Implants.bioRxiv : the preprint server for biology · 2026Article
- Augmentation Mastopexy Using a Submuscular Inferior Pectoralis Muscle Sling: An Outcome Analysis of Breast Animation Deformity and Reoperation Rates.Aesthetic plastic surgery · 2026Article
- Apolipoprotein E knockout attenuates vascular graft fibrosis by reducing profibrotic macrophage formation through low-density lipoprotein receptor related protein 1.Bioactive materials · 2026Article
- Immunomodulatory topographies regulate myofibroblast differentiation and influence fibrous encapsulation of glaucoma drainage devices.Bioactive materials · 2026Article
- Long-Term Hydrophilic, Anti-Clotting, and Anti-Fibrotic Dynamic Covalent Silicone-Based Biomaterials.Advanced healthcare materials · 2026Article
- Systematic biocompatibility assessment of 4-µm surface silicone implants.Biomaterials and biosystems · 2026Article
- Ergonomic Implants: A Single Centre Experience in Post-Mastectomy Breast Reconstruction.Medicina (Kaunas, Lithuania) · 2026Observational
- Breast Implants: Biomaterials, Surfaces, Biocompatibility-A Biomedical Engineering Perspective.Journal of clinical medicine · 2026Review
- Enabling adaptability and hydraulic resistance in minimally invasive glaucoma surgery using an architecture-driven approach.iScience · 2026Article
- Piezo1-A Key Pathogenic Factor in Breast Implant-Associated Capsular Contracture.Aesthetic plastic surgery · 2026Article
- Microbial Contamination-Mediated Inflammation Is a Major Contributor of Breast Implant Complications: Prospective Analysis of 631 Samples.Journal of clinical medicine · 2026Article
91 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 11 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Silicone is widely used in chronic implants and is generally perceived to be safe. However, textured breast implants have been associated with immune-related complications, including malignancies. Here, by examining for up to one year the foreign body response and capsular fibrosis triggered by miniaturized or full-scale clinically approved breast implants with different surface topography (average roughness, 0-90 μm) placed in the mammary fat pads of mice or rabbits, respectively, we show that surface topography mediates immune responses to the implants. We also show that the surface surrounding human breast implants collected during revision surgeries also differentially alters the individual's immune responses to the implant. Moreover, miniaturized implants with an average roughness of 4 μm can largely suppress the foreign body response and fibrosis (but not in T-cell-deficient mice), and that tissue surrounding these implants displayed higher levels of immunosuppressive FOXP3
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.