Evidence map›Paper›PMID 34155309›Full record

ArticleScientific reports2021

SIRT2 promotes murine melanoma progression through natural killer cell inhibition.

Manchao Zhang, Scarlett Acklin, John Gillenwater, Wuying Du, Mousumi Patra, Hao Yu, Bo Xu, Jianhua Yu, Fen Xia

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  3. Article
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  8. Review
  9. Role of sirtuins in esophageal cancer: Current status and future prospects.World journal of gastrointestinal oncology · 2022
    Review
  10. Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Manchao Zhang *Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.
Scarlett Acklin *Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.
John GillenwaterDepartment of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.
Wuying DuDepartment of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.
Mousumi PatraDepartment of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.
Hao YuDepartment of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.
Bo XuDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA, USA.
Jianhua YuDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA, USA.
Fen XiaDepartment of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA. fxia@uams.edu.
University of Arkansas for Medical Sciences · USCity Of Hope National Medical Center · US

Funding

The Tumor Microenvironmental Barrier to Effective Viral OncolysisP01CA163205 · NCI · OHIO STATE UNIVERSITY · PI Xiaokui Mo · 2013 to 2026
$26.0M
Targeting FLT3 for the Treatment of Relapsed or Refractory Acute Myeloid LeukemiaR01CA265095 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI BUDDE, LIHUA ELIZABETH, CALIGIURI, MICHAEL A · 2021 to 2025
$2.4M
Characterizing and Targeting the Novel IL-15- AKT-XBP1s Pathway in NK CellsR01CA247550 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI YU, JIANHUA · 2020 to 2024
$2.2M
Elucidate and Modulate Cell Signaling in NK Cells for Glioma TreatmentR01AI129582 · NIAID · OHIO STATE UNIVERSITY · PI YU, JIANHUA · 2017 to 2021
$2.1M
Novel functions of Pyruvate kinase M2 in DNA double-strand break repairR01CA188500 · NCI · UNIV OF ARKANSAS FOR MED SCIS · PI CHAKRAVARTI, ARNAB, XIA, FEN · 2014 to 2019
$2.0M
GSK3b mediates radiation-induced cytotoxicity in hippocampal neuronsR01CA163838 · NCI · UNIV OF ARKANSAS FOR MED SCIS · PI XIA, FEN · 2012 to 2016
$1.9M
Overcoming Barriers of Virotherapy by Next-Generation oHSV Expressing E-CadherinR01NS106170 · NINDS · OHIO STATE UNIVERSITY · PI YU, JIANHUA · 2018 to 2023
$1.9M
Enhancing NK Cell Activity by Dietary Diphyllin Lignans for Cancer PreventionR01CA185301 · NCI · OHIO STATE UNIVERSITY · PI CALIGIURI, MICHAEL A, YU, JIANHUA · 2015 to 2019
$1.8M
scFvPD1-FLT3 CAR T Cells for the Treatment of Relapsed Acute Myeloid LeukemiaR21CA223400 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI YU, JIANHUA · 2019 to 2020
$414k
NCI NIH HHS P01 CA163205NCI NIH HHS R01 CA163838NCI NIH HHS R01 CA185301NCI NIH HHS R01 CA188500NCI NIH HHS R01 CA247550NCI NIH HHS R01 CA265095NCI NIH HHS R21 CA223400NIAID NIH HHS R01 AI129582NIH HHS R01 CA188500NINDS NIH HHS R01 NS106170
6 · The paper itself

Abstract

SIRT2, an NAD

Indexed as

ImmunomodulationAnimalsBiomarkersCell Line, TumorCell MovementDisease ProgressionKiller Cells, NaturalLymphocytes, Tumor-InfiltratingMelanomaMelanoma, ExperimentalMiceSirtuin 2Tumor MicroenvironmentBiomarkersSirtuin 2

Identifiers

PMID34155309
PMCPMC8217567
OpenAlexW3176309999

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.