ArticleScientific reports2021
Multiscale modelling of cerebrovascular injury reveals the role of vascular anatomy and parenchymal shear stresses.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 19 citations in OpenAlex.
- Mechanobiology of the blood-brain barrier during development, disease and ageing.Nature communications · 2025Review
- The biomechanical signature of loss of consciousness: computational modelling of elite athlete head injuries.Brain : a journal of neurology · 2023Review
- Mechanisms of mechanical load transfer through brain tissue.Scientific reports · 2023Article
- Use of Brain Biomechanical Models for Monitoring Impact Exposure in Contact Sports.Annals of biomedical engineering · 2022Review
- The Protective Performance of Modern Motorcycle Helmets Under Oblique Impacts.Annals of biomedical engineering · 2022Article
- Finding the Spatial Co-Variation of Brain Deformation With Principal Component Analysis.IEEE transactions on bio-medical engineering · 2022Article
- A Finite Element Model of Cerebral Vascular Injury for Predicting Microbleeds Location.Frontiers in bioengineering and biotechnology · 2022Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Neurovascular injury is often observed in traumatic brain injury (TBI). However, the relationship between mechanical forces and vascular injury is still unclear. A key question is whether the complex anatomy of vasculature plays a role in increasing forces in cerebral vessels and producing damage. We developed a high-fidelity multiscale finite element model of the rat brain featuring a detailed definition of the angioarchitecture. Controlled cortical impacts were performed experimentally and in-silico. The model was able to predict the pattern of blood-brain barrier damage. We found strong correlation between the area of fibrinogen extravasation and the brain area where axial strain in vessels exceeds 0.14. Our results showed that adjacent vessels can sustain profoundly different axial stresses depending on their alignment with the principal direction of stress in parenchyma, with a better alignment leading to larger stresses in vessels. We also found a strong correlation between axial stress in vessels and the shearing component of the stress wave in parenchyma. Our multiscale computational approach explains the unrecognised role of the vascular anatomy and shear stresses in producing distinct distribution of large forces in vasculature. This new understanding can contribute to improving TBI diagnosis and prevention.
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