ArticleScientific reports2021
Contrast sensitivity and higher-order aberrations in Keratoconus subjects.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Keratoconus and quality of life: an updated comprehensive review.BMC ophthalmology · 2025Pooled it
- Three-year outcomes of customized transepithelial corneal cross-linking with oxygen supplementation in keratoconus.BMC ophthalmology · 2026Article
- Effect of Chromatic Aberration on White-Light Contrast Sensitivity With Higher-Order Monochromatic Aberrations Correction in the Human Eye in Screen-Based Vision.Translational vision science & technology · 2026Article
- Evaluation of Factors Influencing Quality of Life in Keratoconus Patients Using the Keratoconus Outcomes Research Questionnaire (KORQ).Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Strategies for Early Keratoconus Diagnosis: A Narrative Review of Evaluating Affordable and Effective Detection Techniques.Journal of clinical medicine · 2025Review
- Relationship between objective and subjective refraction measurements in patients with mild keratoconus.International journal of ophthalmology · 2025Article
- Comparison of the quantitative contrast sensitivity function between early keratoconus and normal eyes.BMC ophthalmology · 2024Article
- Impact of Scleral Lenses on Visual Acuity and Ocular Aberrations in Corneal Ectasia: A Comprehensive Review.Journal of personalized medicine · 2024Review
- Corneal aberrations are associated with low-energy meniscus injuries.BMC ophthalmology · 2024Observational
- An Arduino-Powered Device for the Study of White Perception beyond the Visual Chromatic Critical Flicker Fusion Frequency.Journal of imaging · 2024Article
- Assessment of a Clinical Test for Detection of Alteration in Visual Perception Due to Astigmatism.Clinical ophthalmology (Auckland, N.Z.) · 2024Article
- Structure-Function Relationship in Keratoconus: Spatial and Depth Vision.Translational vision science & technology · 2023Article
- A novel tool for quantitative measurement of distortion in keratoconus.Eye (London, England) · 2023Article
- Best indices of dual Scheimpflug/Placido tomographer for keratoconus detection.International ophthalmology · 2023Article
- The Characteristics of Quick Contrast Sensitivity Function in Keratoconus and Its Correlation with Corneal Topography.Ophthalmology and therapy · 2023Article
- Efficacy of custom-made soft keratoconus lenses on corneal aberrations and photic phenomena in patients with keratoconus: a corneal topography imaging based study.International journal of ophthalmology · 2023Article
- Suprathreshold Contrast Perception Is Altered by Long-term Adaptation to Habitual Optical Blur.Investigative ophthalmology & visual science · 2022Article
- Corneal higher-order aberration changes after accelerated cross-linking for keratoconus.BMC ophthalmology · 2022Article
- Vision related quality of life in keratoconus patients with intra stromal corneal ring segments implantation.Oman journal of ophthalmologyArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study analyzes the relationship between contrast-sensitivity and higher-order aberrations (HOA) in mild and subclinical-keratoconus in subjects with good visual-acuity (VA). Keratoconus group (including subclinical-keratoconus) and controls underwent autokeratometry, corneal-tomography, autorefraction and HOA measurement. Contrast-sensitivity was tested using a psychophysical two-alternative forced-choice Gabor patches in three blocks (6, 9, 12 cycles/deg). Controls were compared to the keratoconus group and to a keratoconus subgroup with VA of 0.00 LogMar group ("keratoconus-0.00VA"). Spearman correlation tested association between HOA and contrast-sensitivity. Twenty-two keratoconus subjects (38 eyes: 28 keratoconus, 10 subclinical-keratoconus, 20 keratoconus-0.00VA) and 35 controls were included. There was a significant difference between control and keratoconus, and between control and keratoconus-0.00VA, for keratometry, cylinder, thinnest and central corneal thickness (p < 0.001). Controls showed lower HOA and higher contrast-sensitivity for all spatial-frequencies (p < 0.001). Most HOA were negatively correlated with contrast-sensitivity for all spatial-frequencies for keratoconus group and for 9 and 12 cycles/deg for keratoconus-0.00VA. Keratoconus subjects with good VA showed reduction in contrast-sensitivity and increased HOAs compared to controls. HOA and contrast-sensitivity are inversely correlated in subjects with mild keratoconus despite good VA. This suggests that the main mechanism underlying the decreased vision quality in keratoconus is the increase of HOA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.