Evidence map›Paper›PMID 34155238›Full record

ArticleScientific reports2021

Quality of life in keratoconus: evaluation with Keratoconus Outcomes Research Questionnaire (KORQ).

Roberto Damian Pacheco Pinto, Ricardo Yuji Abe, Flávia Cid Gomes, Paulo Rodolfo Tagliari Barbisan, Alexandre Fattah Martini, Daniel de Almeida Borges, Arthur Gustavo Fernandes, Carlos Eduardo Leite Arieta, Monica Alves

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Trends in the Management of Keratoconus in Australia.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026
    Article
  3. Article
  4. Evaluation of Factors Influencing Quality of Life in Keratoconus Patients Using the Keratoconus Outcomes Research Questionnaire (KORQ).Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026
    Article
  5. Article
  6. Review
  7. Impact of contact lens correction on wavefront aberrations and vision quality in keratoconus.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Experiences of keratoconus patients attending public eye care facilities in South Africa.African journal of primary health care & family medicine · 2024
    Article
  13. Article
  14. Quality of life of a sample of people with keratoconus in KSA.Journal of Taibah University Medical Sciences · 2023
    Article
  15. Article
  16. Quality of life and tomography indices in patients with keratoconus.The Journal of international medical research · 2023
    Article
  17. Article
  18. Quality of life in patients with keratoconus.Indian journal of ophthalmology · 2022
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Roberto Damian Pacheco PintoDepartment of Ophthalmology and Otorhinolaryngology, University of Campinas, Campinas, São Paulo, Brazil. rpacheco42@gmail.com.
Ricardo Yuji AbeDepartment of Ophthalmology and Otorhinolaryngology, University of Campinas, Campinas, São Paulo, Brazil.
Flávia Cid GomesDepartment of Ophthalmology and Otorhinolaryngology, University of Campinas, Campinas, São Paulo, Brazil.
Paulo Rodolfo Tagliari BarbisanDepartment of Ophthalmology and Otorhinolaryngology, University of Campinas, Campinas, São Paulo, Brazil.
Alexandre Fattah MartiniDepartment of Ophthalmology and Otorhinolaryngology, University of Campinas, Campinas, São Paulo, Brazil.
Daniel de Almeida BorgesDepartment of Ophthalmology and Otorhinolaryngology, University of Campinas, Campinas, São Paulo, Brazil.
Arthur Gustavo FernandesDepartamento de Oftalmologia e Ciências Visuais, Escola Paulista de Medicina, Universidade Federal de São Paulo - UNIFESP, São Paulo, SP, Brazil.
Carlos Eduardo Leite ArietaDepartment of Ophthalmology and Otorhinolaryngology, University of Campinas, Campinas, São Paulo, Brazil.
Monica AlvesDepartment of Ophthalmology and Otorhinolaryngology, University of Campinas, Campinas, São Paulo, Brazil.
Universidade Estadual de Campinas (UNICAMP) · BRUniversidade Federal de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To assess the quality of life of keratoconus patients using the Keratoconus Outcomes Research Questionnaire (KORQ), translated and validated in Portuguese language. The KORQ is the only validated keratoconus specific questionnaire and has a high rating for its psychometric properties. This cross-sectional study enrolled 100 keratoconus patients from a tertiary referral eye hospital between April 2018 and June 2019. Associations between age, sex, allergic conjunctivitis, keratoconus stage, best-corrected visual acuity (BCVA), maximum simulated keratometry (Kmax), steep keratometry (K2), pachymetry, treatments performed, hydrops, and KORQ scores were evaluated using univariate (Wilcoxon test and the Kruskal Wallis test) and multivariate linear regression with stepwise backward modeling. Lower KORQ scores are associated with better quality of life, whereas, higher scores are associated with greater impairment of functional activities and symptoms. Among the 100 patients, mild, moderate, and severe keratoconus were observed in 15%, 46% and 39% of participants, respectively. Univariate analysis showed lower function scores values, with male sex (p < 0.05) and both functional and symptom scores were significantly associated with BCVA < 0.3 (LogMAR) (p < 0.05). Multivariate analysis indicated significantly lower functional scores in individuals with BCVA < 0.3 (LogMAR) (p < 0.001) and those with a history of crosslinking treatment (p = 0.022), while symptom scores were only significantly associated with only BCVA < 0.3 (LogMAR) (p < 0.001). In patients with keratoconus, BCVA in the better eye and history of crosslinkig were factors associated with better quality of life scores using the KORQ.

Indexed as

Quality of LifeAdolescentAdultComorbidityCorneal TopographyFemaleHumansKeratoconusMaleMiddle AgedOutcome Assessment, Health CarePublic Health SurveillanceSeverity of Illness IndexSurveys and QuestionnairesSymptom AssessmentVisual Acuity

Identifiers

PMID34155238
PMCPMC8217221
OpenAlexW3174295058

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.