ArticleScientific reports2021
Phenotypic and genomic hallmarks of a novel, potentially pathogenic rapidly growing Mycobacterium species related to the Mycobacterium fortuitum complex.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 16 citations in OpenAlex.
- From colonisation to chronicity: adaptation ofMicrobiology (Reading, England) · 2026Article
- Taxonomic landscape of theFrontiers in microbiology · 2026Article
- Systemic Infection Caused by Mycobacterium fortuitum Following Aortic Valve Transplantation-Employing Combined Molecular Techniques for Accurate Species Identification.Current microbiology · 2025Article
- Harnessing hypoxia: bacterial adaptation and chronic infection in cystic fibrosis.FEMS microbiology reviews · 2025Review
- Improving the treatment of bacterial infections caused by multidrug-resistant bacteria through drug repositioning.Frontiers in pharmacology · 2024Review
- Prosthetic joint infection caused by an imipenem-resistant Mycobacterium senegalense.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- A nontuberculous mycobacterium could solve the mystery of the lady from the Franciscan church in Basel, Switzerland.BMC biology · 2023Article
- Culture-Independent PCR Detection and Differentiation ofPathogens (Basel, Switzerland) · 2022Article
- Antibiotic delivery evaluation against Mycobacterium fortuitum using nanofluids containing carbon nanotubes.BMC microbiology · 2022Article
- Comparative genome analysis reveals high-level drug resistance markers in a clinical isolate ofFrontiers in cellular and infection microbiology · 2022Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previously, we have identified a putative novel rapidly growing Mycobacterium species, referred to as TNTM28, recovered from the sputum of an apparently immunocompetent young man with an underlying pulmonary disease. Here we provide a thorough characterization of TNTM28 genome sequence, which consists of one chromosome of 5,526,191 bp with a 67.3% G + C content, and a total of 5193 predicted coding sequences. Phylogenomic analyses revealed a deep-rooting relationship to the Mycobacterium fortuitum complex, thus suggesting a new taxonomic entity. TNTM28 was predicted to be a human pathogen with a probability of 0.804, reflecting the identification of several virulence factors, including export systems (Sec, Tat, and ESX), a nearly complete set of Mce proteins, toxin-antitoxins systems, and an extended range of other genes involved in intramacrophage replication and persistence (hspX, ahpC, sodA, sodC, katG, mgtC, ClpR, virS, etc.), some of which had likely been acquired through horizontal gene transfer. Such an arsenal of potential virulence factors, along with an almost intact ESX-1 locus, might have significantly contributed to TNTM28 pathogenicity, as witnessed by its ability to replicate efficiently in macrophages. Overall, the identification of this new species as a potential human pathogen will help to broaden our understanding of mycobacterial pathogenesis.
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