Evidence map›Paper›PMID 34155205›Full record

ArticleNature communications2021

ERRγ enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes.

Kenji Miki, Kohei Deguchi, Misato Nakanishi-Koakutsu, Antonio Lucena-Cacace, Shigeru Kondo, Yuya Fujiwara, Takeshi Hatani, Masako Sasaki, Yuki Naka, Chikako Okubo and 11 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.

  1. Pooled it
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  3. Review
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  5. Connexin 43-Enriched Vesicles Improve Synchronization in hiPSC-Derived Cardiomyocytes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  20. Short-Term Electrical Stimulation Impacts Cardiac Cell Structure and Function.Journal of tissue engineering and regenerative medicine · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 2 institutions in 1 country.

Kenji Miki *Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.ORCID 0000-0001-7901-6133
Kohei Deguchi *Takeda-CiRA Joint program (T-CiRA), Fujisawa, Japan.
Misato Nakanishi-Koakutsu *Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.
Antonio Lucena-CacaceCenter for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.ORCID 0000-0002-1181-2683
Shigeru KondoTakeda-CiRA Joint program (T-CiRA), Fujisawa, Japan.
Yuya FujiwaraCenter for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.
Takeshi HataniCenter for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.ORCID 0000-0002-4204-2706
Masako SasakiCenter for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.
Yuki NakaCenter for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.
Chikako OkuboCenter for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.ORCID 0000-0001-5562-410X
Megumi NaritaCenter for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.ORCID 0000-0002-8198-4042
Ikue TakeiCenter for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.
Stephanie C NapierTakeda-CiRA Joint program (T-CiRA), Fujisawa, Japan.ORCID 0000-0001-9611-566X
Tsukasa SugoGenAhead Bio Inc., Fujisawa, Japan.
Sachiko ImaichiPharmaceutical Science, Takeda Pharmaceutical Company Limited, Fujisawa, Japan.
Taku MonjoIBL, Takeda Pharmaceutical Company Limited, Fujisawa, Japan.
Tatsuya AndoIBL, Takeda Pharmaceutical Company Limited, Fujisawa, Japan.
Norihisa TamuraTakeda-CiRA Joint program (T-CiRA), Fujisawa, Japan.
Kenichi ImahashiTakeda-CiRA Joint program (T-CiRA), Fujisawa, Japan.
Tomoyuki NishimotoTakeda-CiRA Joint program (T-CiRA), Fujisawa, Japan. tomoyuki.nishimoto@takeda.com.
Yoshinori YoshidaCenter for iPS Cell Research and Application, Kyoto University, Kyoto, Japan. yoshinor@cira.kyoto-u.ac.jp.ORCID 0000-0001-5511-9090
Kyoto University · JPTakeda (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

One of the earliest maturation steps in cardiomyocytes (CMs) is the sarcomere protein isoform switch between TNNI1 and TNNI3 (fetal and neonatal/adult troponin I). Here, we generate human induced pluripotent stem cells (hiPSCs) carrying a TNNI1

Indexed as

Cell DifferentiationGene Expression RegulationGenes, ReporterHumansInduced Pluripotent Stem CellsModels, BiologicalMyocytes, CardiacReceptors, EstrogenSarcolemmaSarcomeresS-Phase Kinase-Associated ProteinsTranscriptomeTroponin IESRRG protein, humanReceptors, EstrogenS-Phase Kinase-Associated ProteinsTNNI1 protein, humanTNNI3 protein, humanTroponin I

Identifiers

PMID34155205
PMCPMC8217550
OpenAlexW3175941182

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.