Evidence map›Paper›PMID 34155011›Full record

ArticleBMJ case reports2021

Bilateral macular drusen in acquired partial lipodystrophy with type 2 membranoproliferative glomerulonephritis.

Alexander Tanner, Hwei Wuen Chan, Anna Stears, Mariya Moosajee

Open access · greenAbstract readCase Reports
In one paragraph

Article in BMJ case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. A Narrative Review of C3 Glomerulopathy: From Pathogenesis to Targeted Therapy.Canadian journal of kidney health and disease · 2026
    Review
  2. Observational
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Alexander TannerMoorfields Eye Hospital NHS Foundation Trust, London, UK.
Hwei Wuen ChanMoorfields Eye Hospital NHS Foundation Trust, London, UK.
Anna StearsNational Severe Insulin Resistance Service, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Mariya MoosajeeMoorfields Eye Hospital NHS Foundation Trust, London, UK m.moosajee@ucl.ac.uk.
University College London · GBCambridge University Hospitals NHS Foundation Trust · GBMoorfields Eye Hospital · GB

Funding

Wellcome Trust 205174/Z/16/Z
6 · The paper itself

Abstract

A 35-year-old woman with acquired partial lipodystrophy (PLD) and features of type 2 membranoproliferative glomerulonephritis (MPGN-II), presented with difficulty in her fine detailed vision over the past year. She had right amblyopia from a hypermetropic anisometropia with astigmatism, displaying a best-corrected visual acuity of 0.50 and 0.00 LogMAR, in the right and left eye, respectively. Funduscopy showed bilateral symmetrical drusenoid deposits most prominent in the temporal macula with clusters in the superior and inferior retina, outside the temporal vascular arcades. Multimodal retinal imaging was performed, which confirmed hyperautofluorescent drusen located between the retinal pigment epithelium and Bruch's membrane. Electroretinography showed bilateral mild peripheral macular dysfunction, but normal central macular function on the pattern electroretinogram. Both PLD and macular drusen, are rare as distinct disease entities, but an association does exist and may be linked to MPGN-II.

Indexed as

Glomerulonephritis, MembranoproliferativeLipodystrophyRetinal DrusenAdultBruch MembraneFemaleHumansRetinal Pigment Epitheliumlipid disordersmaculametabolic disordersretina

Identifiers

PMID34155011
PMCPMC8217924
OpenAlexW3173837462

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.