ArticleTropical medicine and health2021
Risk factors associated with mechanical ventilation, autonomic nervous dysfunction and physical outcome in Vietnamese adults with tetanus.
Article in Tropical medicine and health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- Mortality and risk factors in hospitalised adult patients with tetanus: a systematic review and meta-analysis.BMJ open · 2025Pooled it
- Clinical and epidemiological profile of patients with accidental tetanus in a referral hospital: a 13-year historical series.Infection · 2026Article
- Clinical characteristics, management, and outcomes of severe tetanus in the intensive care unit.BMC infectious diseases · 2026Observational
- Tetanus: recognition and management.The Lancet. Infectious diseases · 2025Review
- Factors Influencing the Length of Emergency Intensive Care Unit Stay in Adult Tetanus Patients.International journal of general medicine · 2025Article
- Adult patients with tetanus in Slovenia 2006-2021 : Results of a national cohort study.Wiener klinische Wochenschrift · 2023Article
Corrections and comments
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Authors and funding
22 authors at 8 institutions in 3 countries.
Funding
Abstract
backgroundTetanus remains common in many low- and middle-income countries, but as critical care services improve, mortality from tetanus is improving. Nevertheless, patients develop severe syndromes associated with autonomic nervous system disturbance (ANSD) and the requirement for mechanical ventilation (MV). Understanding factors associated with worse outcome in such settings is important to direct interventions. In this study, we investigate risk factors for disease severity and long-term physical outcome in adults with tetanus admitted to a Vietnamese intensive care unit.
methodsClinical and demographic variables were collected prospectively from 180 adults with tetanus. Physical function component scores (PCS), calculated from Short Form Health Survey (SF-36), were assessed in 79 patients at hospital discharge, 3 and 6 months post discharge.
resultsAge, temperature, heart rate, lower peripheral oxygen saturation (SpO
conclusionsMV and ANSD may be suitable endpoints for future research. Risk factors for reduced physical function at 3 months and 6 months post discharge suggest that modifiable features during hospital management are important determinants of long-term outcome.
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