Evidence map›Paper›PMID 34154667›Full record

ReviewCardio-oncology (London, England)2021

A new classification of cardio-oncology syndromes.

Rudolf A de Boer, Joseph Pierre Aboumsallem, Valentina Bracun, Douglas Leedy, Richard Cheng, Sahishnu Patel, David Rayan, Svetlana Zaharova, Jennifer Rymer, Jennifer M Kwan and 4 more

Abstract readReview
In one paragraph

Review in Cardio-oncology (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

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  17. Cardio-oncology rehabilitation: are we ready?European heart journal supplements : journal of the European Society of Cardiology · 2024
    Article
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Rudolf A de BoerDepartment of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Joseph Pierre AboumsallemDepartment of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Valentina BracunDepartment of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Douglas LeedyDivision of Cardiology, Department of Medicine, University of Washington, Seattle, WA, USA.
Richard ChengDivision of Cardiology, Department of Medicine, University of Washington, Seattle, WA, USA.
Sahishnu PatelDepartment of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
David RayanDepartment of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Svetlana ZaharovaCardio-Oncology Program, Division of Cardiovascular Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA.
Jennifer RymerDuke University, Durham, NC, USA.
Jennifer M KwanSection of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT, USA.
Joshua LevensonHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Claudio RoncoDepartment of Medicine, University of Padova, Padova, Italy.
Paaladinesh ThavendiranathanDivision of Cardiology, Toronto General Hospital, Toronto, Canada.
Sherry-Ann BrownCardio-Oncology Program, Division of Cardiovascular Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA. shbrown@mcw.edu.ORCID http://orcid.org/0000-0002-5687-7632

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
H2020 European Research Council 818715NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

Increasing evidence suggests a multifaceted relationship exists between cancer and cardiovascular disease (CVD). Here, we introduce a 5-tier classification system to categorize cardio-oncology syndromes (COS) that represent the aspects of the relationship between cancer and CVD. COS Type I is characterized by mechanisms whereby the abrupt onset or progression of cancer can lead to cardiovascular dysfunction. COS Type II includes the mechanisms by which cancer therapies can result in acute or chronic CVD. COS Type III is characterized by the pro-oncogenic environment created by the release of cardiokines and high oxidative stress in patients with cardiovascular dysfunction. COS Type IV is comprised of CVD therapies and diagnostic procedures which have been associated with promoting or unmasking cancer. COS Type V is characterized by factors causing systemic and genetic predisposition to both CVD and cancer. The development of this framework may allow for an increased facilitation of cancer care while optimizing cardiovascular health through focused treatment targeting the COS type.

Indexed as

CancerCardiac TumoursCardio-oncologyCardiotoxicityCardiovascular diseaseHeart failureImmune systemInflammationMedical diagnostic radiationPreventionPrognostic biomarkers

Identifiers

PMID34154667
PMCPMC8218489

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.