ArticleGenome medicine2021
Genetic correlation and causal relationships between cardio-metabolic traits and lung function impairment.
Article in Genome medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Genome-wide association study of preserved ratio impaired spirometry (PRISm).The European respiratory journal · 2024Pooled it
- Gut microbiome and frailty: insight from genetic correlation and mendelian randomization.Gut microbes · 2023Pooled it
- Causal links between gut microbiota, plasma metabolites, and insomnia: Insights from Mendelian randomization.Dialogues in clinical neuroscience · 2026Article
- Association of dietary patterns with the prevalence of rheumatic diseases among older Chinese adults: a national cross-sectional survey.Clinical rheumatology · 2026Article
- Constructing a protein-protein interaction network for autoimmune liver diseases by integrating pQTL, rQTL, and mediation analyses.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Multi-omics integration identifies associations between large high-density lipoprotein and lung function, asthma, and COPD: evidence from genetic and population-based analyses.Respiratory research · 2026Article
- Partitioned polygenic scores show mechanistic heterogeneity in type 2 diabetes and hypertension comorbidity.Nature communications · 2026Article
- Exploring the Genetic Association and Genetic Architecture of Iridocyclitis and Extraocular Autoimmune Diseases.Translational vision science & technology · 2026Article
- Multi-omics reveals cholesterol-driven macrophage metabolic reprogramming and inflammation in chronic obstructive pulmonary disease.Genome medicine · 2026Article
- Association between metabolic score for visceral fat and adverse outcomes in chronic obstructive pulmonary disease.BMJ open respiratory research · 2026Article
- Elucidating the causal effects of plasma metabolites on breast cancer from multiple perspectives.International journal of surgery (London, England) · 2026Article
- Association of forced expiratory volume in 0.5 seconds/forced vital capacity ratio with all-cause mortality in adults: a cohort study.Journal of thoracic disease · 2025Article
- Genetic underpinnings of the heterogeneous impact of obesity on lipid levels and cardiovascular disease.Genome medicine · 2025Article
- Association between depression and asthma: insight from observational and genetic evidence.BMC psychiatry · 2025Observational
- Integrative multi-omics investigation of sleep apnea: gut microbiome metabolomics, proteomics and phenome-wide association study.Nutrition & metabolism · 2025Article
- Roles of Gut Microbiota and Associated Metabolites inPolish journal of microbiology · 2025Article
- Dissecting cross-population polygenic heterogeneity across respiratory and cardiometabolic diseases.Nature communications · 2025Article
- Mendelian randomization evidence for lung function mediates the association between childhood allergies (age <16 years) and essential hypertension.Reproductive and developmental medicine · 2025Article
- The role of gut microbiota and plasma metabolites in ulcerative colitis: Insights from Mendelian randomization analysis.Medicine · 2025Article
- Causal relationship between uterine fibroids and cardiovascular disease: A two-sample Mendelian randomization study.Medicine · 2025Article
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundAssociations of low lung function with features of poor cardio-metabolic health have been reported. It is, however, unclear whether these co-morbidities reflect causal associations, shared genetic heritability or are confounded by environmental factors.
methodsWe performed three analyses: (1) cardio-metabolic health to lung function association tests in Northern Finland Birth cohort 1966, (2) cross-trait linkage disequilibrium score regression (LDSC) to compare genetic backgrounds and (3) Mendelian randomisation (MR) analysis to assess the causal effect of cardio-metabolic traits and disease on lung function, and vice versa (bidirectional MR). Genetic associations were obtained from the UK Biobank data or published large-scale genome-wide association studies (N > 82,000).
resultsWe observed a negative genetic correlation between lung function and cardio-metabolic traits and diseases. In Mendelian Randomisation analysis (MR), we found associations between type 2 diabetes (T2D) instruments and forced vital capacity (FVC) as well as FEV1/FVC. Body mass index (BMI) instruments were associated to all lung function traits and C-reactive protein (CRP) instruments to FVC. These genetic associations provide evidence for a causal effect of cardio-metabolic traits on lung function. Multivariable MR suggested independence of these causal effects from other tested cardio-metabolic traits and diseases. Analysis of lung function specific SNPs revealed a potential causal effect of FEV1/FVC on blood pressure.
conclusionsThe present study overcomes many limitations of observational studies by using Mendelian Randomisation. We provide evidence for an independent causal effect of T2D, CRP and BMI on lung function with some of the T2D effect on lung function being attributed to inflammatory mechanisms. Furthermore, this analysis suggests a potential causal effect of FEV1/FVC on blood pressure. Our detailed analysis of the interplay between cardio-metabolic traits and impaired lung function provides the opportunity to improve the quality of existing intervention strategies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.