ArticleGut pathogens2021
Virulence among different types of hypervirulent Klebsiella pneumoniae with multi-locus sequence type (MLST)-11, Serotype K1 or K2 strains.
Article in Gut pathogens, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 31 citations in OpenAlex.
- Comparative profiling of virulence determinants, capsular serotypes, and antimicrobial resistance in hypervirulent and classical Klebsiella pneumoniae isolates from liver abscess patients.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Article
- The sero-prevalence and virulence determinants ofMicrobiology spectrum · 2026Article
- Convergence of multidrug resistance and efflux-mediated biocide tolerance in klebsiella pneumoniae ST307: implications for nosocomial infection control in Iranian hospitals.BMC infectious diseases · 2025Article
- New insights and perspectives on the virulence of hypervirulent Klebsiella pneumoniae.Folia microbiologica · 2025Review
- Molecular and genetic features of a blaAnnals of clinical microbiology and antimicrobials · 2025Article
- Molecular Characterization and Risk Factors of Carbapenem-Resistant HypervirulentInfection and drug resistance · 2025Article
- Molecular analysis ofOpen veterinary journal · 2025Article
- Singleplex real-time PCR and duplex PCR platform for the rapid detection of hypervirulentFrontiers in veterinary science · 2025Article
- Genotypic diversity and virulence factors of Klebsiella pneumoniae in a North Indian tertiary care hospital.BMC infectious diseases · 2024Article
- In Vitro and In Vivo Assessments of Newly Isolated N4-like Bacteriophage against ST45 K62 Capsular-Type Carbapenem-ResistantInternational journal of molecular sciences · 2024Article
- Genetic Analyses of Rare ESBL ST628Microorganisms · 2024Article
- Comparison of virulence factors between ESBL and non-ESBL producingIranian journal of microbiology · 2024Article
- Molecular Characteristics of Virulence Genes in Carbapenem-Resistant and Carbapenem-SensitiveInfection and drug resistance · 2024Article
- HypervirulentPathogens & immunity · 2024Review
- A 20-Year Study of Capsular Polysaccharide Seroepidemiology, Susceptibility Profiles, and Virulence Determinants of Klebsiella pneumoniae from Bacteremia Patients in Taiwan.Microbiology spectrum · 2023Article
- Covert dissemination of pLVPK-like virulence plasmid in ST29-K54 Klebsiella pneumoniae: emergence of low virulence phenotype strains.Frontiers in cellular and infection microbiology · 2023Article
- Development and validation of a prediction model based on clinical and CT features for invasiveness of K. pneumoniae liver abscess.European radiology · 2022Article
- Combing Immunoinformatics with Pangenome Analysis To Design a Multiepitope Subunit Vaccine against Klebsiella pneumoniae K1, K2, K47, and K64.Microbiology spectrum · 2022Article
- Phenotypic and Genotypic Characterization of a Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae ST17-KL38 Clinical Isolate Harboring the Carbapenemase IMP-4.Microbiology spectrum · 2022Article
- Three Novel Sequence Types Carbapenem-Resistant Klebsiella pneumoniae Strains ST5365, ST5587, ST5647 Isolated from Two Tertiary Teaching General Hospitals in Shanxi Province, in North China: Molecular Characteristics, Resistance and Virulence Factors.Infection and drug resistance · 2022Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundTwo different types of hypervirulent K. pneumoniae (HvKp), the MLST-11 and serotype K1/K2 strains, have been frequently described in recent studies. Although these two types of strains were described to be HvKp, their virulence was not compared. In this study, in vitro and in vivo approaches were used to assess differences in virulence. MATERIALS AND
methodsA total of twenty-nine isolates, including 6 strains of each of serotype K1 and K2 isolates and 17 strains of ST11 isolates, were selected for this study. Phenotypic tests of virulence were performed by the string test and analysis of the virulent associated genes was detected by PCR. In vitro models of serum resistance and phagocytosis were used as the parameters to assess the virulence. In-frame deletion of virulence-associated genes was performed to study their contributions to virulence. The median lethal dose, i.e., the LD
resultsAlthough serotype K1 and K2 strains and ST11 isolates had similar virulence gene profiles, the ST11 isolates showed less serum and phagocytic resistance than the serotype K1/K2 isolates. The mouse lethality test revealed that all ST11 isolates were unable to cause lethality, even at > 10
conclusionSince there was a significant difference in virulence levels between the two types of HvKp when assessed in in vitro and in vivo models, it may be better to use the designation "HvKp" for some strains based on animal studies to avoid confusion. Virulence and non-virulence could be analysed in a relative manner, especially in comparison studies.
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