ArticleBMC endocrine disorders2021
Does vitamin D supplementation improve ovarian reserve in women with diminished ovarian reserve and vitamin D deficiency: a before-and-after intervention study.
Article in BMC endocrine disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05393011 (Vitamin D and Some Antioxidants and Trace Elements Levels in Women), which is not on this map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Vitamin D and Some Antioxidants and Trace Elements Levels in Women: Relationship With I.V.F Outcomes
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- A meta-analysis of the literature evaluating the impact of vitamin D on female fertility and ovarian reserve function.Revista da Escola de Enfermagem da U S P · 2026Pooled it
- The impact of vitamin D supplementation on anti-Müllerian hormone levels: a systematic review and meta-analysis.BMC endocrine disorders · 2025Pooled it
- The auxiliary effect of oral nutritional supplements on fertility in women with diminished ovarian reserve: a systematic review and meta-analysis.Annals of medicine · 2025Pooled it
- Low serum anti-Müllerian hormone is associated with semen quality in infertile men and not influenced by vitamin D supplementation.BMC medicine · 2023Trial
- Association of Ethnicity With Ovarian Reserve: A Systematic Review and Meta-Analysis.Health science reports · 2026Review
- Molecular mechanisms and multi-organ regulatory roles of anti-Müllerian hormone in female reproduction.Communications biology · 2026Review
- Association of Deficiency in Vitamin D, Vitamin E, and Selenium Levels With Premature Ovarian Insufficiency: A Systematic Review.Health science reports · 2025Review
- The role of diet and food supplements in infertility management in the Eastern Mediterranean Region: A narrative review.International journal of reproductive biomedicine · 2025Review
- Ovarian reserve modulates the impact of vitamin D deficiency on assisted reproductive outcomes in patients undergoing controlled ovarian hyperstimulation.Frontiers in nutrition · 2024Article
- Anti-Müllerian hormone: biology and role in endocrinology and cancers.Frontiers in endocrinology · 2024Review
- Diminished ovarian reserve is associated to euploidy rate: a single center study.Frontiers in endocrinology · 2024Article
- The Associations of Vitamin D with Ovarian Reserve Markers and Depression: A Narrative Literature Review.Nutrients · 2023Review
- Websites Selling Direct-to-Consumer Anti-Mullerian Hormone Tests.JAMA network open · 2023Article
- The role of serum vitamin D in patients with normal ovarian reserve undergoing the first IVF/ICSI cycle.Frontiers in endocrinology · 2023Article
- The association between Diet Quality Index-International score and risk of diminished ovarian reserve: a case-control study.Frontiers in nutrition · 2023Article
- Correlation between 25-hydroxy vitamin D levels in women and in vitro fertilization outcomes: A cross-sectional study.Annals of medicine and surgery (2012) · 2022Article
- Proteomic Analysis of Human Follicular Fluid Reveals the Pharmacological Mechanisms of the Chinese Patent Drug Kunling Pill for Improving Diminished Ovarian Reserve.Evidence-based complementary and alternative medicine : eCAM · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveEvaluation of vitamin D supplementation on ovarian reserve in women with diminished ovarian reserve and vitamin D deficiency.
methodsThe study is a before-and-after intervention study that was performed on women with diminished ovarian reserve referred to Shahid Mofteh Clinic in Yasuj, Iran. Eligible women were prescribed vitamin D tablets at a dose of 50,000 units weekly for up to 3 months. Serum levels of vitamin D and AMH were evaluated at the end of 3 months. Significance level was also considered P ≤ 0.05.
resultsOur results have been showed there was a statistically significant difference in vitamin D levels of participants before [12.1(6.5)] and after [26(9.15)] the intervention (P < 0.001). Moreover, there was a statistically significant difference in serum AMH levels of participants before [0.50(0.44)] and after [0.79(0.15)] the intervention (P=0.02 ).
conclusionIn conclusion, the results of the current study support a possible favorable effect of vitamin D on increase AMH expression by acting on the AMH gene promoter. Therefore, it is possible that vitamin D increases AMH levels without changing the antral follicle count/ovarian reserve.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.