ArticleBMC pregnancy and childbirth2021
Knowledge and intake of folic acid to prevent neural tube defects among pregnant women in urban China: a cross-sectional study.
Article in BMC pregnancy and childbirth, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Does previous pregnancy experience improve folic acid supplementation uptake? A systematic review and meta-analysis.BMJ open · 2026Pooled it
- [Development and validation of a comprehensive evaluation index system for preconception health behaviors in reproduc-tive-aged populations].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2026Article
- Caring for Early Pregnancy, Empowering Healthy Beginnings: Strengthening the Health Foundation of Youth Fertility in China on World Population Day 2026.China CDC weekly · 2026Article
- Association of premarital medical check-ups and folic acid knowledge, attitudes, and practices with the occurrence of neural tube defects in Guangxi, China (2009-2023).Journal of global health · 2026Article
- The critical gap in prevention: knowledge of periconception folic acid supplementation and its predictors among pregnant women in Ethiopia.Maternal health, neonatology and perinatology · 2026Article
- Burden of neural tube defects in the Middle East and North Africa from 1990 to 2021: Findings from the global burden of disease study.Journal of Taibah University Medical Sciences · 2025Article
- Parental Characteristics Associated With Children Born With Neural Tube Defects in Puebla, Mexico.Cureus · 2025Article
- Prevalence of and factors associated with unintended pregnancy and association with depressive symptoms among pregnant women in Guangdong, China: a multicentre cross-sectional study.BMC psychiatry · 2025Article
- Preconception folic acid utilization and associated factors among reproductive-age women in Lemi Kura Sub City, Addis Ababa, Ethiopia, 2024.BMC pregnancy and childbirth · 2025Article
- Scientific and Public Health Challenges in Folic Acid Supplementation: Insights from Brazil and Global Implications.Nutrients · 2025Review
- Article
- Maternal and gestational factors associated with congenital anomalies among live births: a nationwide population-based study in Brazil from 2012 to 2020.BMC pregnancy and childbirth · 2025Article
- Risk factors for neural tube defects in the war and siege-affected tigray regional state of ethiopia: a case-control study.BMC pregnancy and childbirth · 2025Article
- Folic acid supplementation on congenital heart disease and its dual character.Current research in pharmacology and drug discovery · 2025Review
- National strategies for screening neural tube defects in Saudi Arabia: activating prevention and early intervention.Frontiers in public health · 2025Review
- Maternal Serum Folate During Pregnancy and Congenital Heart Disease in Offspring.JAMA network open · 2024Article
- Knowledge, awareness, and use of folic acid among women of childbearing age living in a peri-urban community in Ghana: a cross-sectional survey.BMC pregnancy and childbirth · 2024Article
- Spina Bifida Prevention: A Narrative Review of Folic Acid Supplements for Childbearing Age Women.Cureus · 2024Review
- Analyzing the Trends and Causes of Birth Defects - Jinan City, Shandong Province, China, 2005-2022.China CDC weekly · 2023Article
- Association of Maternal Folate Intake and Offspring MTHFD1 and MTHFD2 Genes with Congenital Heart Disease.Nutrients · 2023Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe prevalence of neural tube defects (NTDs) in China declined during 2000-2017 with periconceptional folic acid (FA) supplementation, which is effective in reducing the risk of birth defects. We aimed to assess the knowledge and actual use of FA among Chinese pregnant women and to explore factors associated with FA use before pregnancy.
methodsAll data were collected in face-to-face interviews during health visits among pregnant women. We collected information about knowledge and use of FA supplements and demographic, socioeconomic, and health status. One maternity and childcare hospital was chosen in each of four cities: Beijing, Huaibei, Kunming, and Haikou. In total, 435 pregnant women were randomly recruited for interviews conducted from June to December 2016.
resultsA total of 428 pregnant women were included in this survey. Of these, 82.0% (351/428) knew that FA can prevent NTDs, and 75.9% (325/428) knew the correct time to take FA. Overall, 65.9% (282/428) of women knew both that FA can prevent NTDs and the recommended time to take FA before pregnancy. Approximately 95.1% (407/428) of women reported having ever taken FA, only 46.3% (198/428) had begun to take FA supplementation before conception, and 64.5% (109/169) of women from rural areas failed to take FA before pregnancy. Women living in northern China (odds ratio [OR] = 1.81, 95% confidence interval [CI], 1.18-2.77), those with unplanned pregnancy (OR = 1.99, 95% CI 1.30-3.04), and highly educated women (OR = 2.37, 95% CI 1.45-3.88) were more likely to know about FA. Women who were homemakers (OR = 1.94, 95% CI 1.21-3.11) and had unplanned pregnancy (OR = 6.18, 95% CI 4.01-9.53) were less likely to begin taking FA before pregnancy.
conclusionsOur survey showed that most pregnant women knew about FA. Although preconception intake of FA can help to reduce NTDs, improving the rate of FA intake before pregnancy is needed in urban areas of China, especially among homemakers and women from rural areas or with unplanned pregnancy. Campaigns are needed to increase awareness about FA and FA use before pregnancy among rural women, homemakers, and those with unplanned pregnancy and lower education levels.
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