ArticleBMC medical research methodology2021
The minimal perceived change: a formal model of the responder definition according to the patient's meaning of change for patient-reported outcome data analysis and interpretation.
Article in BMC medical research methodology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Meaningful change threshold estimation for the non-small cell lung cancer symptom assessment questionnaire (NSCLC-SAQ): psychometric analysis from a phase 3 trial (LIBRETTO-431).Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Trial
- Estimating the minimal important change of single-item measures using the adjusted predictive modeling method or the longitudinal confirmatory factor analysis method.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- A weighted predictive modeling method for estimating thresholds of meaningful within-individual change for patient-reported outcomes.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- Conceptualizing meaningful between-group difference in change over time: a demonstration of possible viewpoints.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- The psychometric properties of the amharic version of EuroQoL five-dimensions-five level among Ethiopian cervical cancer patients.Health and quality of life outcomes · 2024Article
- Effect of present state bias on minimal important change estimates: a simulation study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Article
- The MIDQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Article
- Anchor-based minimal important difference values are often sensitive to the distribution of the change score.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Article
- Estimating anchor-based minimal important change using longitudinal confirmatory factor analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Article
- Estimating meaningful thresholds for multi-item questionnaires using item response theory.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023Article
- Introduction to the special section: "Methodologies and considerations for meaningful change".Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023Article
- Establishing thresholds for meaningful within-individual change using longitudinal item response theory.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023Article
- Minimal Clinically Important Difference Estimates Are Biased by Adjusting for Baseline Severity, Not by Regression to the Mean.Journal of athletic training · 2022Article
- Triangulation of multiple meaningful change thresholds for patient-reported outcome scores.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021Review
- Interpretation of Change in Novel Digital Measures: A Statistical Review and Tutorial.Digital biomarkersReview
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundPatient-Reported Outcomes (PROs) are standardized questionnaires used to measure subjective outcomes such as quality of life in healthcare. They are considered paramount to assess the results of therapeutic interventions. However, because their calibration is relative to internal standards in people's mind, changes in PRO scores are difficult to interpret. Knowing the smallest value in the score that the patient perceives as change can help. An estimator linking the answers to a Patient Global Rating of Change (PGRC: a question measuring the overall feeling of change) with change in PRO scores is frequently used to obtain this value. In the last 30 years, a plethora of methods have been used to obtain these estimates, but there is no consensus on the appropriate method and no formal definition of this value.
methodsWe propose a model to explain changes in PRO scores and PGRC answers.
resultsA PGRC measures a construct called the Perceived Change (PC), whose determinants are elicited. Answering a PGRC requires discretizing a continuous PC into a category using threshold values that are random variables. Therefore, the populational value of the Minimal Perceived Change (MPC) is the location parameter value of the threshold on the PC continuum defining the switch from the absence of change to change.
conclusionsWe show how this model can help to hypothesize what are the appropriate methods to estimate the MPC and its potential to be a rigorous theoretical basis for future work on the interpretation of change in PRO scores.
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Registered trials
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