Evidence map›Paper›PMID 34154444›Full record

ArticleJournal of the American Psychiatric Nurses Association

Caregiver-Reported Burden in RE-KINECT: Data From a Prospective Real-World Tardive Dyskinesia Screening Study.

Andrew J Cutler, Stanley N Caroff, Caroline M Tanner, Huda Shalhoub, William R Lenderking, Véronique Pagé, Ericha Franey, Chuck Yonan

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Psychiatric Nurses Association. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03062033 (Real-World Evaluation Screening Study and Registry of Dyskinesia in Patients Taking Antipsychotic Agents), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03062033 unknown statusnot on this map

Real-World Evaluation Screening Study and Registry of Dyskinesia in Patients Taking Antipsychotic Agents

Typeobservational_patient_registrySponsorNeurocrine BiosciencesRan2017 to 2018Enrolled70ConditionsTardive Dyskinesia
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Telehealth for Assessing and Managing Tardive Dyskinesia: Expert Insights from a Cross-Disciplinary Virtual Treatment Panel.Telemedicine journal and e-health : the official journal of the American Telemedicine Association · 2023
    Article
  6. Article
  7. Review
  8. Pathophysiology, prognosis and treatment of tardive dyskinesia.Therapeutic advances in psychopharmacology · 2022
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Andrew J CutlerAndrew J. Cutler, MD, SUNY Upstate Medical University, Syracuse, NY, USA.ORCID 0000-0001-5800-0378
Stanley N CaroffStanley N. Caroff, MD, Department of Psychiatry, Corporal Michael J. Crescenz Veterans Affairs Medical Center and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Caroline M TannerCaroline M. Tanner, MD, PhD, Neurology, UCSF School of Medicine and San Francisco VA Health Care System, San Francisco, CA, USA.
Huda ShalhoubHuda Shalhoub, PhD, Evidera, Waltham, MA, USA.
William R LenderkingWilliam R. Lenderking, PhD, Patient Centered Research, Evidera, Waltham, MA, USA.
Véronique PagéVéronique Pagé, MSc, Evidera, Montreal, Quebec, Canada.
Ericha FraneyEricha Franey, PhD, Medical Affairs, Neurocrine Biosciences, Inc., San Diego, CA, USA.
Chuck YonanChuck Yonan, PharmD, Medical Affairs, Neurocrine Biosciences, Inc., San Diego, CA, USA.
Neurocrine Biosciences (United States) · USSan Francisco VA Health Care System · USSUNY Upstate Medical University · USUniversity of Pennsylvania · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRE-KINECT (NCT03062033), a real-world study of possible tardive dyskinesia (TD) in antipsychotic-treated patients, included a questionnaire to assess the effects of patients' abnormal involuntary movements on caregivers.

aimsTo capture the experiences of caregivers who assisted individuals with abnormal involuntary movements that were confirmed by clinicians as being consistent with TD.

methodsQualified (nonpaid) caregivers were invited to complete a questionnaire that included the following: caregivers' sociodemographic characteristics, their perceptions about the impact of abnormal involuntary movements on patients, and the impact of these movements on themselves (caregivers).

resultsOf the 41 participating caregivers, 25 (61.0%) were women, 20 (48.8%) were employed full time or part time, and 35 (85.4%) were family members or friends. Based on responses from caregivers who noticed patients' abnormal involuntary movements and were caring for individuals who also noticed those movements, 48.0% of patients had "a lot" of severity in ≥1 body region and 76.0% had abnormal involuntary movements in ≥2 regions. Caregiver ratings were significantly correlated with patient ratings (but not with clinician ratings) for maximum severity of abnormal involuntary movements and the number of affected regions (both

conclusionsCaregivers as well as patients are negatively affected by TD, and the impact of TD on caregivers' lives should be considered when determining treatment options.

Indexed as

bipolar/mood disorderfamilies of the mentally illqualitative researchschizoaffective disorderschizophreniatardive dyskinesia

Identifiers

PMID34154444
PMCPMC10492432
OpenAlexW3175093992

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.