ArticlemBio2021
Linking a Gene Cluster to Atranorin, a Major Cortical Substance of Lichens, through Genetic Dereplication and Heterologous Expression.
Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 66 citations in OpenAlex.
- Methyl 4-O-Demethylbarbatate Destabilises HIF-1α and Enhances Temozolomide Sensitivity in Glioma Cells.Cell proliferation · 2026Article
- Siderophore production by the lichen fungus Xanthoria parietina supports its algal symbiont.Nature communications · 2026Article
- Deciphering the biosynthetic pathways of lichen acids.The New phytologist · 2026Article
- Unveiling Lichen's Hidden Arsenal Against Multidrug Resistance: A Systematic Review of Their Essential Oils, Volatile Compounds and Extracts with Antimicrobial Applications.Microorganisms · 2026Review
- Paired-omics-based exploration and characterization of biosynthetic diversity in lichenized fungi.Microbial genomics · 2025Article
- Heterologous expression of anChemical science · 2025Article
- The Role of Nucleotide Sequencing in Natural Product Drug Discovery.Journal of natural products · 2025Review
- A Biosynthetic and Taxonomic Atlas of the Global Lichen Holobiont.Environmental microbiology · 2025Article
- Functional heterologous expression of the reversibleEngineering microbiology · 2025Article
- Lichens are a treasure chest of bioactive compounds: fact or fake?The New phytologist · 2025Article
- Breaking into nature's secret medicine cabinet: lichens - a biochemical goldmine ready for discovery.The New phytologist · 2025Review
- Genome Mining-Guided Discovery of Two New Depsides fromMarine drugs · 2025Article
- Lichens and Health-Trends and Perspectives for the Study of Biodiversity in the Antarctic Ecosystem.Journal of fungi (Basel, Switzerland) · 2025Review
- Genomic features of lichen-associated black fungi.IUBMB life · 2025Article
- Article
- Are there conserved biosynthetic genes in lichens? Genome-wide assessment of terpene biosynthetic genes suggests ubiquitous distribution of the squalene synthase cluster.BMC genomics · 2024Article
- Investigation of Antimicrobial Compounds Produced by Endolichenic Fungi in Different Culture Media.The plant pathology journal · 2024Article
- Discovery and Heterologous Expression of Functional 4-Journal of natural products · 2024Article
- A Review of Laboratory Requirements to Culture Lichen Mycobiont Species.Journal of fungi (Basel, Switzerland) · 2024Review
- The Depside Derivative Pericodepside Inhibits Cancer Cell Metastasis and Proliferation by Suppressing Epithelial-Mesenchymal Transition.ACS omega · 2024Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The depside and depsidone series compounds of polyketide origin accumulate in the cortical or medullary layers of lichen thalli. Despite the taxonomic and ecological significance of lichen chemistry and its pharmaceutical potentials, there has been no single piece of genetic evidence linking biosynthetic genes to lichen substances. Thus, we systematically analyzed lichen polyketide synthases (PKSs) for categorization and identification of the biosynthetic gene cluster (BGC) involved in depside/depsidone production. Our in-depth analysis of the interspecies PKS diversity in the genus
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