Evidence map›Paper›PMID 34154412›Full record

ArticlemBio2021

The

Taylor G Glausen, Gabriela L Carrillo, Richard M Jin, Jon P Boyle, Jeroen P J Saeij, Elizabeth A Wohlfert, Michael A Fox, Ira J Blader

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Dense granule proteins: key mediators ofFrontiers in medicine · 2026
    Review
  2. Article
  3. mBio · 2025
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Taylor G GlausenDepartment of Microbiology and Immunology, SUNY at Buffalo School of Medicine, Buffalo, New York, USA.
Gabriela L CarrilloCenter for Neurobiology Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, Virginia, USA.
Richard M JinDepartment of Microbiology and Immunology, SUNY at Buffalo School of Medicine, Buffalo, New York, USA.
Jon P BoyleDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Jeroen P J SaeijDepartment of Pathology, Microbiology, and Immunology, University of California, Davis, Davis, California, USA.
Elizabeth A WohlfertDepartment of Microbiology and Immunology, SUNY at Buffalo School of Medicine, Buffalo, New York, USA.
Michael A FoxCenter for Neurobiology Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, Virginia, USA.
Ira J BladerDepartment of Microbiology and Immunology, SUNY at Buffalo School of Medicine, Buffalo, New York, USA.
University at Buffalo, State University of New York · USBiomedical Research Institute · USUniversity of California, Davis · USUniversity of Pittsburgh · US

Funding

Toxoplasma gondii Regulation of Host GABAergic SignalingR01AI124677 · NIAID · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI BLADER, IRA J, FOX, MICHAEL A · 2016 to 2020
$2.7M
Toxoplasma induces phagocytosis of perisomatic inhibitory synapsesF99NS120596 · NINDS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI CARRILLO, GABRIELA LIZANA · 2020 to 2021
$82k
NIAID NIH HHS R01 AI124677NINDS NIH HHS F99 NS120596
6 · The paper itself

Abstract

Toxoplasmic encephalitis can develop in individuals infected with the protozoan parasite Toxoplasma gondii and is typified by parasite replication and inflammation within the brain. Patients often present with seizures, but the parasite genes and host pathways involved in seizure development and/or propagation are unknown. We previously reported that seizure induction in

Indexed as

AnimalsBrainFemaleGene ExpressionGenome, ProtozoanHost-Parasite InteractionsHumansInterleukin-1betaMiceMice, Inbred C57BLProtozoan ProteinsSeizuresSignal TransductionToxoplasmaToxoplasmosis, AnimalVirulence FactorsInterleukin-1betaProtozoan ProteinsVirulence Factorsencephalitishost-parasite relationshipneuroimmunologyToxoplasma gondii

Identifiers

PMID34154412
PMCPMC8262954
OpenAlexW3174785217

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.