Evidence map›Paper›PMID 34154399›Full record

ArticlemBio2021

Inhibitory Concentrations of Ciprofloxacin Induce an Adaptive Response Promoting the Intracellular Survival of Salmonella enterica Serovar Typhimurium.

Sushmita Sridhar, Sally Forrest, Derek Pickard, Claire Cormie, Emily A Lees, Nicholas R Thomson, Gordon Dougan, Stephen Baker

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Journal of bacteriology · 2024
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Sushmita SridharDepartment of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.
Sally ForrestDepartment of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.
Derek PickardDepartment of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.
Claire CormieDepartment of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.
Emily A LeesDepartment of Paediatrics, University of Oxford, Oxford, United Kingdom.
Nicholas R ThomsonWellcome Sanger Institute, Hinxton, United Kingdom.
Gordon DouganDepartment of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.
Stephen BakerDepartment of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.
University of Cambridge · GBUniversity of Oxford · GBWellcome Sanger Institute · GB

Funding

Department of Health NIHR200640Wellcome TrustWellcome Trust 206194Wellcome Trust 215515/Z/19/Z
6 · The paper itself

Abstract

Antimicrobial resistance (AMR) is a pressing global health crisis, which has been fueled by the sustained use of certain classes of antimicrobials, including fluoroquinolones. While the genetic mutations responsible for decreased fluoroquinolone (ciprofloxacin) susceptibility are known, the implications of ciprofloxacin exposure on bacterial growth, survival, and interactions with host cells are not well described. Aiming to understand the influence of inhibitory concentrations of ciprofloxacin

Indexed as

Anti-Bacterial AgentsBacterial ProteinsCiprofloxacinGene Expression ProfilingHumansMicrobial Sensitivity TestsMicrobial ViabilitySalmonella InfectionsSalmonella typhimuriumSerogroupTranscription, GeneticAnti-Bacterial AgentsBacterial ProteinsCiprofloxacinAMRantimicrobial agentscellular morphologyciprofloxacinconfocal microscopySalmonellatranscriptomics

Identifiers

PMID34154399
PMCPMC8262899
OpenAlexW3174401927

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.