SynthesisThe American journal of psychiatry2021
Disrupted Dorsal Mid-Insula Activation During Interoception Across Psychiatric Disorders.
Synthesis in The American journal of psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 3 of them syntheses that pooled it.
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Who cites it
47 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Neural correlates of altered interoception in depressive and anxiety disorders: a systematic review and meta-analysis.European archives of psychiatry and clinical neuroscience · 2026Pooled it
- Psychological interventions for interoception in mental health disorders: A systematic review of randomized-controlled trials.Psychiatry and clinical neurosciences · 2023Pooled it
- Common and specific patterns of functional and structural brain alterations in schizophrenia and bipolar disorder: a multimodal voxel-based meta-analysis.Journal of psychiatry & neuroscience : JPNPooled it
- General and anxiety-linked influences of acute serotonin reuptake inhibition on neural responses associated with attended visceral sensation.Translational psychiatry · 2024Trial
- Trial
- Selective interoception impairments and treatment effects in borderline personality disorder.Translational psychiatry · 2026Article
- Comparative insights into insula structure and function.Nature neuroscience · 2026Review
- Transdiagnostic alterations of intrinsic brain activity in major psychiatric disorders.European archives of psychiatry and clinical neuroscience · 2026Article
- Beyond bendy joints: number of variant connective tissue features predicts neurodivergent characteristics in hypermobile individuals with anxiety.Npj mental health research · 2026Article
- Behavioral and neural mechanisms underlying contextual processing in naturalistic short video viewing.iScience · 2026Article
- The relationship between interoception of breathing, anxiety, and resting-state functional connectivity in the brain.Cognitive, affective & behavioral neuroscience · 2025Article
- Exposure to early-life stress uncovers shared biological signatures underlying vulnerability in the habenula and insular cortex of male and female adult rats.Neurobiology of stress · 2025Article
- Cardiac Signals Facilitate the Breakthrough to Awareness of Emotional Stimuli.Psychophysiology · 2025Article
- An interoceptive model of energy allostasis linking metabolic and mental health.Science advances · 2025Review
- Interoceptive Dysfunction in Psychiatric Disorders and Non-invasive Neuromodulation for Improving Interoception.Neuroscience bulletin · 2025Review
- Structural Connectivity Differences Reflect Microstructural Heterogeneity of the Human Insular Cortex.Human brain mapping · 2025Article
- A multicenter cross-sectional study to elucidate altered resting-state functional connectivity of the insular cortex in anorexia nervosa, segmented by functional localization.Scientific reports · 2025Article
- Direct interoceptive input to the insular cortex shapes learned feeding behavior.bioRxiv : the preprint server for biology · 2025Article
- Habenula contributions to negative self-cognitions.Nature communications · 2025Article
- Breaking through the mind-body divide: patient priorities for interoception research.EClinicalMedicine · 2025Article
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3 authors.
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Abstract
objectiveMaintenance of bodily homeostasis relies on interoceptive mechanisms in the brain to predict and regulate bodily state. While altered neural activation during interoception in specific psychiatric disorders has been reported in many studies, it is unclear whether a common neural locus underpins transdiagnostic interoceptive differences.
methodsThe authors conducted a meta-analysis of neuroimaging studies comparing patients with psychiatric disorders with healthy control subjects to identify brain regions exhibiting convergent disrupted activation during interoception. Bibliographic, neuroimaging, and preprint databases through May 2020 were searched. A total of 306 foci from 33 studies were extracted, which included 610 control subjects and 626 patients with schizophrenia, bipolar or unipolar depression, posttraumatic stress disorder, anxiety, eating disorders, or substance use disorders. Data were pooled using a random-effects model implemented by the activation likelihood estimation algorithm. The preregistered primary outcome was the neuroanatomical location of the convergence of peak voxel coordinates.
resultsConvergent disrupted activation specific to the left dorsal mid-insula was found (Z=4.47, peak coordinates: -36, -2, 14; volume: 928 mm
conclusionsThese results reveal transdiagnostic, domain-general differences in interoceptive processing in the left dorsal mid-insula. Disrupted mid-insular activation may represent a neural marker of psychopathology and a putative target for novel interventions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.