Evidence map›Paper›PMID 34154323›Full record

ArticleJournal of the American Chemical Society2021

Dph3 Enables Aerobic Diphthamide Biosynthesis by Donating One Iron Atom to Transform a [3Fe-4S] to a [4Fe-4S] Cluster in Dph1-Dph2.

Yugang Zhang, Dan Su, Boris Dzikovski, Sean H Majer, Rachael Coleman, Siddarth Chandrasekaran, Michael K Fenwick, Brian R Crane, Kyle M Lancaster, Jack H Freed and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Integrative analysis of the role of theTranslational cancer research · 2024
    Article
  2. Article
  3. Biomolecules · 2023
    Article
  4. Yeast geneMicrobial cell (Graz, Austria) · 2023
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Yugang ZhangDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.ORCID 0000-0002-1141-5821
Dan SuDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.ORCID 0000-0003-1224-921X
Boris DzikovskiDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.ORCID 0000-0002-5687-5207
Sean H MajerDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.
Rachael ColemanDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.ORCID 0000-0002-9877-4607
Siddarth ChandrasekaranDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.ORCID 0000-0003-2990-7397
Michael K FenwickDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.ORCID 0000-0001-5066-4962
Brian R CraneDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.ORCID 0000-0001-8234-9991
Kyle M LancasterDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.ORCID 0000-0001-7296-128X
Jack H FreedDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.ORCID 0000-0003-4288-2585
Hening LinDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.ORCID 0000-0002-0255-2701
Cornell University · USHoward Hughes Medical Institute · US

Funding

TR&D 4 for ACERT, 2017-2021 funding periodP41GM103521 · NIGMS · CORNELL UNIVERSITY · PI FREED, JACK H · 2012 to 2021
$11.7M
Molecular Mechanisms of Signal Transduction Involving Light, Redox and Transmembrane ComplexesR35GM122535 · NIGMS · CORNELL UNIVERSITY · PI BRIAN R CRANE · 2017 to 2026
$7.1M
Post-Fixation Nitrogen Cycle MetalloenzymologyR35GM124908 · NIGMS · CORNELL UNIVERSITY · PI Kyle M Lancaster · 2017 to 2026
$3.4M
Metabolite Sensing and Regulation of Protein FunctionR35GM131808 · NIGMS · CORNELL UNIVERSITY · PI LIN, HENING · 2019 to 2023
$1.9M
NIGMS NIH HHS P41 GM103521NIGMS NIH HHS R35 GM122535NIGMS NIH HHS R35 GM124908NIGMS NIH HHS R35 GM131808
6 · The paper itself

Abstract

All radical

Indexed as

DithioniteHistidineIronIron-Sulfur ProteinsPeptide Elongation Factor 2Repressor ProteinsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsS-AdenosylmethioninediphthamideDithioniteDph1 protein, S cerevisiaeDPH2 protein, S cerevisiaeHistidineIronIron-Sulfur ProteinsKTI11 protein, S cerevisiaePeptide Elongation Factor 2Repressor ProteinsSaccharomyces cerevisiae ProteinsS-Adenosylmethionine

Identifiers

PMID34154323
PMCPMC8251694
OpenAlexW3177049128

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.