ArticleNature2021
Dysregulation of brain and choroid plexus cell types in severe COVID-19.
Erratum issuedOpen access · bronzeAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 384 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
384citing papers in PubMed, 3 pooled it
57.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
384 citing papers in PubMed, 3 syntheses or guidelines pooled it, 600 citations in OpenAlex.
- Pooled it
- A systematic review of biologically-informed deep learning models for cancer: fundamental trends for encoding and interpreting oncology data.BMC bioinformatics · 2023Pooled it
- SARS-Cov-2 infection and neuropathological findings: a report of 18 cases and review of the literature.Acta neuropathologica communications · 2023Pooled it
- Human brain matters: Navigating the neuropathology of COVID-19.Brain pathology (Zurich, Switzerland) · 2026Review
- Drug Repurposing for Treating NCOR-Related Intellectual Disability.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Brain defence by the extracellular matrix protein Cochlin.Communications biology · 2026Article
- Niche-Mediated Neural Priming Enables Robust and Scalable Generation of Human Choroid Plexus Organoids.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- SARS-CoV-2 disrupts the integrity of a human blood-brain barrier model in the absence of infection.Journal of neurovirology · 2026Article
- The choroid plexus is a source of active renin in the central nervous system.Research square · 2026Article
- Longitudinal analysis reveals myeloid cell contributions to murine neuroPASC pathogenesis.Nature communications · 2026Article
- Translational insights into Long-COVID: evaluation of preclinical animal models along the lung-brain-immune axis with focus on Golden Syrian Hamsters.Journal of neuroinflammation · 2026Review
- Brain-engrafted monocyte-derived macrophages from blood and skull-bone marrow exhibit distinct properties.Neuron · 2026Article
- Expanding canonical cortical cell type markers in the era of single-cell transcriptomics.Scientific reports · 2026Article
- Expansion Revealing of Pathology Resolves Nanostructures Associated with Inflammatory Phenotypes in COVID-19 Decedent Human Brain Tissue.bioRxiv : the preprint server for biology · 2026Article
- SARS-CoV-2 Spike Protein S1 Subunit Induces Neuroinflammation Via Microglial Kv1.3 Channel.Biological psychiatry global open science · 2026Article
- EndothelialThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- SARS-CoV-2 infection reduces the number of spermatogonial stem cells and dysregulates the transcriptional landscape of the human testis.Research square · 2026Article
- Sex- and Age-Dependent Neuroimmune Dysregulation and Early Neurodegenerative Signatures Following SARS-CoV-2 Infection in Golden Syrian Hamsters.Research square · 2026Article
- Cross-Organ Neuroimmunology of Behavior.Annual review of immunology · 2026Review
- Choroid plexus modulates subventricular zone adult neurogenesis and olfaction through secretion of small extracellular vesicles.Fluids and barriers of the CNS · 2026Article
324 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
23 authors at 3 institutions in 2 countries.
Andrew C Yang *Department of Bioengineering, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-6756-4746
Fabian Kern *Chair for Clinical Bioinformatics, Saarland University, Saarbrücken, Germany.ORCID http://orcid.org/0000-0002-8223-3750
Patricia M LosadaDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Maayan R AgamDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Christina A MaatDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Georges P SchmartzChair for Clinical Bioinformatics, Saarland University, Saarbrücken, Germany.
Tobias FehlmannChair for Clinical Bioinformatics, Saarland University, Saarbrücken, Germany.ORCID http://orcid.org/0000-0003-1967-2918
Julian A SteinInstitute for Neuropathology, Saarland University Hospital and Medical Faculty of Saarland University, Homburg, Germany.
Nicholas SchaumDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Davis P LeeDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Kruti CalcuttawalaDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Ryan T VestDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Daniela BerdnikDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Nannan LuDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Oliver HahnDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
David GateDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-0481-9657
M Windy McNerneyDepartment of Psychiatry, Stanford University School of Medicine, Stanford, CA, USA.
Divya ChannappaDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Inma CobosDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Nicole LudwigDepartment of Human Genetics, Saarland University, Homburg, Germany.
Walter J Schulz-SchaefferInstitute for Neuropathology, Saarland University Hospital and Medical Faculty of Saarland University, Homburg, Germany.ORCID http://orcid.org/0000-0001-5886-2322
Andreas KellerDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA. andreas.keller@ccb.uni-saarland.de.ORCID http://orcid.org/0000-0002-5361-0895
Tony Wyss-CorayChEM-H, Stanford University, Stanford, CA, USA. twc@stanford.edu.ORCID http://orcid.org/0000-0001-5893-0831
Stanford University · USSaarland University · DENeurosciences Institute · US
Funding
Stanford Alzheimer's Disease Research CenterAdmin Supp: Developing iPSC models for AD and PDP30AG066515 · NIA · STANFORD UNIVERSITY · PI Jennifer Kaci Fairchild · 2020 to 2026
$29.0MStanford Training Program in Aging ResearchT32AG047126 · NIA · STANFORD UNIVERSITY · PI VYJEYANTHI S PERIYAKOIL, TONY WYSS-CORAY · 2014 to 2026
$4.3MTargeting Cerebrovascular TGF Signaling in Alzheimer's DiseaseRF1AG059694 · NIA · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI LUO, JIAN, WYSS-CORAY, TONY · 2018 to 2018
$3.0MNIA NIH HHS P30 AG066515NIA NIH HHS RF1 AG059694NIA NIH HHS T32 AG047126
Abstract
Although SARS-CoV-2 primarily targets the respiratory system, patients with and survivors of COVID-19 can suffer neurological symptoms
Indexed as
AgedAged, 80 and overAstrocytesBrainCell NucleusChoroid PlexusCOVID-19FemaleHumansInflammationMaleMicrogliaMiddle AgedNeuronsSARS-CoV-2Single-Cell Analysis
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.