ArticleCortex; a journal devoted to the study of the nervous system and behavior2021
Modularity and granularity across the language network-A primary progressive aphasia perspective.
Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- The Neurofunctional Correlates of Morphosyntactic and Thematic Impairments in Aphasia: A Systematic Review and Meta-analysis.Neuropsychology review · 2025Pooled it
- Dynamic neurocognitive adaptation: childhood and adult-midlife engagement associated with later-life brain structure and cognition in older adults with and without mild cognitive impairment.Brain imaging and behavior · 2026Article
- Identifying neuropathologic disease in primary progressive aphasia using narrative speech.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Clinicoanatomic localization of iron-rich gliosis in aphasic presentations of globular glial tauopathy.Brain communications · 2026Article
- The role of structural and functional parameters in designing pathology-specific tDCS protocols for primary progressive aphasia.Alzheimer's research & therapy · 2025Article
- Spatial and Temporal Progression of Neurodegeneration in Confirmed and Suspected TDP-43 Type C Pathology.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Wernicke's functional neuroanatomy model of language turns 150: what became of its psychological reflex arcs?Brain structure & function · 2024Review
- Discriminating nonfluent/agrammatic and logopenic PPA variants with automatically extracted morphosyntactic measures from connected speech.Cortex; a journal devoted to the study of the nervous system and behavior · 2024Article
- Phenotypically concordant distribution of pick bodies in aphasic versus behavioral dementias.Acta neuropathologica communications · 2024Article
- Neural mechanisms of sentence production: a volumetric study of primary progressive aphasia.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Why did humans surpass all other primates? Are our brains so different? Part 1.Dementia & neuropsychologia · 2024Review
- Frontotemporal Degeneration with Transactive Response DNA-Binding Protein Type C at the Anterior Temporal Lobe.Annals of neurology · 2023Review
- Language network lateralization is reflected throughout the macroscale functional organization of cortex.Nature communications · 2023Article
- The Wernicke conundrum is misinterpreted.Brain : a journal of neurology · 2023Article
- Temporopolar regions of the human brain.Brain : a journal of neurology · 2023Article
- White matter microstructure and verbal fluency.Brain structure & function · 2022Article
- Neuropathological fingerprints of survival, atrophy and language in primary progressive aphasia.Brain : a journal of neurology · 2022Article
- Case report: Non-Alzheimer's disease tauopathy with logopenic variant primary progressive aphasia diagnosed using amyloid and tau PET.Frontiers in neurology · 2022Article
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Authors and funding
10 authors at 3 institutions in 1 country.
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Abstract
Tests of grammar, repetition and semantics were administered to 62 prospectively enrolled right-handed participants with primary progressive aphasia (PPA). Structural brain images were obtained at the time of testing. Regression analyses uncovered 3 clearly delineated non-overlapping left hemisphere clusters where cortical thinning (atrophy) was significantly correlated with impaired performance. A morphosyntactic cluster associated with the grammaticality of sentence construction was located predominantly within the middle and inferior frontal gyri; a phonolexical cluster associated with language repetition was located in the temporoparietal junction; a lexicosemantic cluster associated with object naming and single word comprehension was located within the middle and anterior parts of the temporal lobe and extended into insular, orbitofrontal, and mediotemporal cortices. Commonality analyses were undertaken to explore whether these three clusters were as modular as indicated by the regression analyses or whether some underlying functional granularity could be uncovered. Modularity was defined as the exclusive association of an anatomical cluster with a single type of language task whereas granularity was defined as the association of a single anatomical cluster with more than one type of language task. The commonality analyses revealed a predominantly modular organization with quantitatively minor instances of inter-cluster granularity. The results also reconfirmed previous work on PPA which had shown that Wernicke's area is not essential for word comprehension, that naming impairments can be based either on deficits of lexical retrieval or word comprehension, and that the essential substrates of word comprehension encompass much wider areas of the temporal lobe than the temporal pole. The anatomy of the language network has traditionally been explored through patients with focal cerebrovascular accidents and experiments based on functional activation. Investigations on PPA are showing that focal neurodegenerations can add new perspectives to existing models of the language network.
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