Evidence map›Paper›PMID 34153267›Full record

ArticleAmerican journal of ophthalmology2021

Long-Term Outcomes of Selective Laser Trabeculoplasty for Open-Angle Glaucoma in the Caribbean.

Tony Realini, Hazel Shillingford-Ricketts, Darra Burt, Goundappa K Balasubramani

Open access · greenAbstract read
In one paragraph

Article in American journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Alternatives to Topical Glaucoma Medication for Glaucoma Management.Clinical ophthalmology (Auckland, N.Z.) · 2023
    Article
  5. Use of selective laser trabeculoplasty as an alternative in patients who developed ocular hypertension after intravitreal dexamethasone implants: a series of 35 eyes.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022
    Observational
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Tony RealiniDepartment of Ophthalmology and Visual Sciences, West Virginia University Eye Institute, Morgantown, West Virginia, USA (T.R.). Electronic address: hypotonyWVU@gmail.com.
Hazel Shillingford-RickettsHarlsbro Medical Center, Roseau, Dominica (H.S.-R.).
Darra BurtSaint Lucia Blind Welfare Association, Castries, Saint Lucia (D.B.).
Goundappa K BalasubramaniDepartment of Epidemiology, Epidemiology Data Center, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA (G.K.B.).
Dominica State College · DMUniversity of Pittsburgh · USWest Virginia University · US

Funding

Glaucoma Management in the African-Derived Developing World Using TrabeculoplastyR01EY023620 · NEI · WEST VIRGINIA UNIVERSITY · PI REALINI, ANTHONY D · 2014 to 2018
$2.2M
NEI NIH HHS R01 EY023620
6 · The paper itself

Abstract

purposeTo characterize long-term clinical outcomes of monotherapy selective laser trabeculoplasty (SLT) in Afro-Caribbean patients with open-angle glaucoma (OAG).

designThis was a post hoc analysis of nearly 8 years (median, 3.2; interquartile range, 2.1-7.1) of pooled data from the West Indies Glaucoma Laser Study and its preliminary study.

methodsSetting: Three eye care practices in Saint Lucia and Dominica.

participantsAfro-Caribbean adults with mild-moderate OAG treated with ≤2 medications (61 in preliminary study, 72 in West Indies Glaucoma Laser Study).

interventionParticipants underwent medication washout, baseline intraocular pressure (IOP) determination, and bilateral 360-degree SLT. Participants were followed for up to 94 months. Repeat SLT was performed according to prespecified criteria.

main outcome measuresThe primary outcome was mean IOP reduction from baseline. The secondary outcome was medication-free survival with SLT repeated as needed.

resultsThe pooled data set included 265 eyes of 133 Afro-Caribbean participants. The mean (standard deviation) baseline IOP was 21.2 (3.4) and 21.2 (3.9) mmHg in right and left eyes, respectively. Over 8 years, the mean IOP ranged from 12.8 to 15.7 mm Hg and from 13.1 to 15.8 mm Hg, respectively (P < .0001 for every comparison with baseline). The median medication-free survival time for initial SLT was 85.4 months in both eyes. The 94-month medication-free survival of SLT repeated as needed was 71.2% and 71.7%, respectively.

conclusionsMonotherapy SLT, repeated as needed, safely provides significant IOP reductions in most Afro-Caribbean adults with primary OAG through nearly 8 years of follow-up and has significant potential to delay or prevent glaucoma-related vision loss in black patients in low-resource regions.

Indexed as

Glaucoma, Open-AngleLaser TherapyTrabeculectomyAdultCaribbean RegionHumansIntraocular PressureTreatment OutcomeWest Indies

Identifiers

PMID34153267
PMCPMC8634933
OpenAlexW3173934388

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.