ReviewAnnual review of biochemistry2021
An Overview of Microcrystal Electron Diffraction (MicroED).
Review in Annual review of biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Modular synthesis of chemically programmable superlattices.Nature materials · 2026Review
- Towards time-resolved MicroED grid preparation using mix-and-inject gas dynamic virtual nozzles.IUCrJ · 2026Article
- Advances of 3D microcrystals electron diffraction for transmembrane protein structure determination.Biophysical journal · 2026Review
- Article
- Single-cell structural biology with intracellular electron crystallography.Nature communications · 2026Article
- Special Issue "Structural Dynamics of Macromolecules".International journal of molecular sciences · 2026Article
- Article
- Strategies for mitigating radiation damage and improving data completeness in 3D electron diffraction of protein crystals.Acta crystallographica. Section D, Structural biology · 2026Article
- An Amino-Thiophene Functionalized Metal-Organic Framework on Fabric for Selective Extraction, Recovery, and Passive Sampling of Gold Ions and Nanoparticles.Chemistry of materials : a publication of the American Chemical Society · 2025Article
- Yield of Protein Crystallization from Metastable Liquid-Liquid Phase Separation.Molecules (Basel, Switzerland) · 2025Article
- Unraveling atomic complexity from frozen samples.Structural dynamics (Melville, N.Y.) · 2025Article
- From Beam Damage to Massive Reaction Amplification under the Electron Microscope: An Ionization-Induced Chain Reaction in Crystals of a Dewar Benzene.ACS central science · 2024Article
- MicroED structure of the C11 cysteine protease clostripain.Journal of structural biology: X · 2024Article
- Controlling Phase in Colloidal Synthesis.ACS nanoscience Au · 2024Review
- Eliminating the missing cone challenge through innovative approaches.Journal of structural biology: X · 2024Article
- The big chill: Growth ofQRB discovery · 2024Review
- Article
- Electron crystallography and dedicated electron-diffraction instrumentation.Acta crystallographica. Section E, Crystallographic communications · 2023Article
- Design and implementation of suspended drop crystallization.bioRxiv : the preprint server for biology · 2023Article
- Absolute Configuration Determination of Chiral API Molecules by MicroED Analysis of Cocrystal Powders Formed Based on Cocrystal Propensity Prediction Calculations.Chemistry (Weinheim an der Bergstrasse, Germany) · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The bedrock of drug discovery and a key tool for understanding cellular function and drug mechanisms of action is the structure determination of chemical compounds, peptides, and proteins. The development of new structure characterization tools, particularly those that fill critical gaps in existing methods, presents important steps forward for structural biology and drug discovery. The emergence of microcrystal electron diffraction (MicroED) expands the application of cryo-electron microscopy to include samples ranging from small molecules and membrane proteins to even large protein complexes using crystals that are one-billionth the size of those required for X-ray crystallography. This review outlines the conception, achievements, and exciting future trajectories for MicroED, an important addition to the existing biophysical toolkit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.