Evidence map›Paper›PMID 34152947›Full record

ArticleEmerging infectious diseases2021

Seroprevalence of SARS-CoV-2 among Blood Donors and Changes after Introduction of Public Health and Social Measures, London, UK.

Gayatri Amirthalingam, Heather Whitaker, Tim Brooks, Kevin Brown, Katja Hoschler, Ezra Linley, Ray Borrow, Colin Brown, Nick Watkins, David J Roberts and 5 more

Abstract read
In one paragraph

Article in Emerging infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Positive anti-SARS-CoV-2 rapid serological test results among asymptomatic blood donors.Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine · 2022
    Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Gayatri Amirthalingam
Heather Whitaker
Tim Brooks
Kevin Brown
Katja Hoschler
Ezra Linley
Ray Borrow
Colin Brown
Nick Watkins
David J Roberts
Danielle Solomon
Charlotte M Gower
Olivier le Polain de Waroux
Nick J Andrews
Mary E Ramsay

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We describe results of testing blood donors in London, UK, for severe acute respiratory disease coronavirus 2 (SARS-CoV-2) IgG before and after lockdown measures. Anonymized samples from donors 17-69 years of age were tested using 3 assays: Euroimmun IgG, Abbott IgG, and an immunoglobulin receptor-binding domain assay developed by Public Health England. Seroprevalence increased from 3.0% prelockdown (week 13, beginning March 23, 2020) to 10.4% during lockdown (weeks 15-16) and 12.3% postlockdown (week 18) by the Abbott assay. Estimates were 2.9% prelockdown, 9.9% during lockdown, and 13.0% postlockdown by the Euroimmun assay and 3.5% prelockdown, 11.8% during lockdown, and 14.1% postlockdown by the receptor-binding domain assay. By early May 2020, nearly 1 in 7 donors had evidence of past SARS-CoV-2 infection. Combining results from the Abbott and Euroimmun assays increased seroprevalence by 1.6%, 2.3%, and 0.6% at the 3 timepoints compared with Euroimmun alone, demonstrating the value of using multiple assays.

Indexed as

COVID-19SARS-CoV-2Antibodies, ViralBlood DonorsCommunicable Disease ControlEnglandHumansImmunoglobulin GLondonPublic HealthSensitivity and SpecificitySeroepidemiologic StudiesUnited KingdomAntibodies, ViralImmunoglobulin Gantibodycoronavirus diseaseCOVID-19Englandrespiratory infectionsSARS-CoV-2serologyseroprevalencesevere acute respiratory syndrome coronavirus 2surveillanceUnited Kingdomviruseszoonoses

Identifiers

PMID34152947
PMCPMC8237903

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.