Evidence map›Paper›PMID 34152867›Full record

ArticleHigh altitude medicine & biology2021

Impact of Pharmacologically Left Shifting the Oxygen-Hemoglobin Dissociation Curve on Arterial Blood Gases and Pulmonary Gas Exchange During Maximal Exercise in Hypoxia.

Glenn M Stewart, Troy J Cross, Michael J Joyner, Steven C Chase, Timothy Curry, Josh Lehrer-Graiwer, Kobina Dufu, Nicholas E Vlahakis, Bruce D Johnson

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in High altitude medicine & biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Glenn M StewartHuman Integrative and Environmental Physiology Laboratory, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0001-5383-0479
Troy J CrossHuman Integrative and Environmental Physiology Laboratory, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA.
Michael J JoynerDepartment of Anesthesia and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Steven C ChaseHuman Integrative and Environmental Physiology Laboratory, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA.
Timothy CurryDepartment of Anesthesia and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Josh Lehrer-GraiwerGlobal Blood Therapeutics, South San Francisco, California, USA.
Kobina DufuGlobal Blood Therapeutics, South San Francisco, California, USA.
Nicholas E VlahakisGlobal Blood Therapeutics, South San Francisco, California, USA.
Bruce D JohnsonHuman Integrative and Environmental Physiology Laboratory, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA.
Mayo Clinic · USGlobal Blood Therapeutics (United States) · USThe University of Sydney · AU

Funding

Variant Hemoglobin and Cardiorespiratory Regulation in HumansR35HL139854 · NHLBI · MAYO CLINIC ROCHESTER · PI JOYNER, MICHAEL J · 2018 to 2024
$5.8M
NHLBI NIH HHS R35 HL139854
6 · The paper itself

Abstract

Stewart, Glenn M., Troy J. Cross, Michael J. Joyner, Steven C. Chase, Timothy Curry, Josh Lehrer-Graiwer, Kobina Dufu, Nicholas E. Vlahakis, and Bruce D. Johnson. Impact of pharmacologically left shifting the oxygen-hemoglobin dissociation curve on arterial blood gases and pulmonary gas exchange during maximal exercise in hypoxia.

Indexed as

OxygenPulmonary Gas ExchangeExercise TestHemoglobinsHumansHypoxiaOxygen ConsumptionHemoglobinsOxygenGBT440hematologyhypoxiamaximal oxygen uptakeoxygen affinity of hemoglobinvoxelotor

Identifiers

PMID34152867
PMCPMC8665803
OpenAlexW3175939176

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.