Evidence map›Paper›PMID 34152824›Full record

ArticleAntimicrobial agents and chemotherapy2021

Renoprotective Effects of Melatonin against Vancomycin-Related Acute Kidney Injury in Hospitalized Patients: a Retrospective Cohort Study.

Thomas S Hong, Kelsey Briscese, Marshall Yuan, Kiran Deshpande, Lauren M Aleksunes, Luigi Brunetti

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Obesity-Related Glomerulosclerosis-How Adiposity Damages the Kidneys.International journal of molecular sciences · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Thomas S HongDepartment of Pharmacy Practice and Administration, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jerseygrid.430387.b, Piscataway, New Jersey, USA.
Kelsey BrisceseDepartment of Pharmacy Practice and Administration, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jerseygrid.430387.b, Piscataway, New Jersey, USA.
Marshall YuanDepartment of Pharmacy Practice and Administration, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jerseygrid.430387.b, Piscataway, New Jersey, USA.
Kiran DeshpandeDepartment of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jerseygrid.430387.b, Piscataway, New Jersey, USA.
Lauren M AleksunesDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jerseygrid.430387.b, Piscataway, New Jersey, USA.
Luigi BrunettiDepartment of Pharmacy Practice and Administration, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jerseygrid.430387.b, Piscataway, New Jersey, USA.
Rutgers, The State University of New Jersey · US

Funding

Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI ROBERT John LAUMBACH · 1988 to 2026
$47.4M
New Jersey Alliance for Clinical Translational Science: NJ ACTSUL1TR003017 · NCATS · RUTGERS BIOMEDICAL/HEALTH SCIENCES-RBHS · PI PANETTIERI, REYNOLD ALEXANDER · 2019 to 2023
$28.9M
Drug Disposition and NephrotoxicityR01GM123330 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI ALEKSUNES, LAUREN M, JOY, MELANIE S · 2018 to 2021
$2.1M
HHS | NIH | National Center for Advancing Translational Sciences (NCATS) UL1TR003017HHS | NIH | National Institute of Environmental Health Sciences (NIEHS) P30ES005022HHS | NIH | National Institute of General Medical Sciences (NIGMS) R01GM123330NCATS NIH HHS UL1 TR003017NIEHS NIH HHS P30 ES005022NIGMS NIH HHS R01 GM123330
6 · The paper itself

Abstract

Vancomycin is associated with nephrotoxicity, and the mechanism may in part be related to oxidative stress.

Indexed as

Acute Kidney InjuryMelatoninAdultAnti-Bacterial AgentsDrug Therapy, CombinationHumansPiperacillin, Tazobactam Drug CombinationRetrospective StudiesVancomycinAnti-Bacterial AgentsMelatoninPiperacillin, Tazobactam Drug CombinationVancomycinacute kidney injuryantioxidantmelatoninvancomycin

Identifiers

PMID34152824
PMCPMC8370200
OpenAlexW3176986560

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.